Literature DB >> 1362360

Receptor autoradiography with 11C and [3H]-labelled ligands visualized by imaging plates.

K Yanai1, J H Ryu, T Watanabe, R Iwata, T Ido.   

Abstract

The distribution of histamine H1, H3, dopamine D1 and D2 receptors in the brain was studied by receptor autoradiography using a high-sensitivity and high-resolution imaging plate system. [3H]Pyrilamine, [3H](R)alpha-methyl-histamine, [11C]SCH23390, and [11C]N-methylspiperone (or [11C]YM-09151-2) were used as ligands to identify H1, H3, D1 and D2 receptors, respectively. Two different receptors (dopamine D2 and histamine H3) could be also labelled simultaneously in a single cryostat-sliced section using [11C]N-methylspiperone and [3H](R)alpha-methylhistamine, respectively. The imaging plate system is useful for receptor autoradiography of positron emitter-labelled and tritium-labelled receptor-ligands because of its high sensitivity.

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Year:  1992        PMID： 1362360     DOI： 10.1097/00001756-199211000-00003

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  4 in total

1.  Pharmacokinetics and biodistribution of samarium-153-labelled OC125 antibody coupled to CITCDTPA in a xenograft model of ovarian cancer.

Authors:  F Kraeber-Bodéré; A Mishra; P Thédrez; A Faivre-Chauvet; M Bardiès; S Imai; J Le Boterff; J F Chatal
Journal:  Eur J Nucl Med       Date:  1996-05

2.  The effect of dopamine D1 receptor stimulation on the up-regulation of histamine H3-receptors following destruction of the ascending dopaminergic neurones.

Authors:  J H Ryu; K Yanai; X L Zhao; T Watanabe
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739

3.  Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors.

Authors:  I Inoue; K Yanai; D Kitamura; I Taniuchi; T Kobayashi; K Niimura; T Watanabe; T Watanabe
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-12       Impact factor: 11.205

4.  A selective endothelin ETA antagonist, BQ-123, inhibits 125I-endothelin-1 (125I-ET-1) binding to human meningiomas and antagonizes ET-1-induced proliferation of meningioma cells.

Authors:  N Kitagawa; K Tsutsumi; M Niwa; S Yamaga; T Anda; H Khalid; A Himeno; K Taniyama; S Shibata
Journal:  Cell Mol Neurobiol       Date:  1994-04       Impact factor: 5.046
  4 in total

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