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Literature DB >> 13620844

The biological activity of soluble antigen-antibody complexes. II. Physical properties of soluble complexes having skin-irritating activity.

Abstract

Soluble BSA-anti-BSA complexes, formed in antigen excess, give immediate skin reactions in normal guinea pigs. The mechanism of the reaction is not that of passive or reversed passive anaphylaxis. The complex itself is toxic. Skin activity of the complex depends on its composition. It has become obvious that the complex composed of two antigen molecules and one antibody molecule, (Ag(2)Ab), does not have the activity, whereas, Ag(3)Ab(2) and more complicated complexes do. The role of complement as well as speculation on the structural changes of antibody-antigen complexes is presented.

Entities: Species

Keywords: ALLERGY/experimental; ANTIGEN-ANTIBODY REACTIONS

Mesh：

Substances：

Year: 1959 PMID： 13620844 PMCID： PMC2136941 DOI： 10.1084/jem.109.2.127

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

11 in total

1. Separation of complete and incomplete Rh antibodies by centrifugation.

Authors: D H CAMPBELL; P STURGEON; J R VINOGRAD
Journal: Science Date: 1955-12-02 Impact factor: 47.728

2. Studies on the biological properties of antigen-antibody complexes. I. Anaphylatic shock induced by soluble antigen-antibody complexes in unsensitized normal guinea pigs.

Authors: F G GERMUTH; G E MCKINNON
Journal: Bull Johns Hopkins Hosp Date: 1957-07

10. Studies on the mechanism of hypersensitivity phenomena. II. The participation of complement in passive cutaneous anaphylaxis of the albino rat.

Authors: A G OSLER; M M HAWRISIAK; Z OVARY; M SIQUEIRA; O G BIER
Journal: J Exp Med Date: 1957-12-01 Impact factor: 14.307

18 in total

7. Investigations of Allergic Liver Injury: I. Light, Fluorescent and Electron Microscopic Study of the Effects of Soluble Immune Aggregates.

Authors: J W Steiner
Journal: Am J Pathol Date: 1961-04 Impact factor: 4.307

8. Comparison of intravenous gamma globulin and a monoclonal anti-Fc receptor antibody as inhibitors of immune clearance in vivo in mice.

Authors: R J Kurlander; J Hall
Journal: J Clin Invest Date: 1986-06 Impact factor: 14.808

9. Immunohistochemical study of arteriolar (simple) hyalinosis in spleen.

Authors: K Krawczyński
Journal: Am J Pathol Date: 1971-02 Impact factor: 4.307

10. Pan- and auto-agglutination in albumin: a serological and immunochemical study of five cases.

Authors: C A Lovett; B P Moore
Journal: Immunology Date: 1968-03 Impact factor: 7.397

The biological activity of soluble antigen-antibody complexes. II. Physical properties of soluble complexes having skin-irritating activity.

1. Separation of complete and incomplete Rh antibodies by centrifugation.

2. Studies on the biological properties of antigen-antibody complexes. I. Anaphylatic shock induced by soluble antigen-antibody complexes in unsensitized normal guinea pigs.

3. Stimulating action of soluble antigen-antibody complexes on normal guinea-pig smooth muscle.

4. Anaphylaxis in the mouse produced with soluble complexes of antigen and antibody.

5. The role of antibody in immune hemolysis.

6. Biological activity of soluble antigen-antibody complexes. I. Skin reactive properties.

7. Diversity of antibodies.

8. The effect of complement in rabbit serum on the quantitative precipitin reaction. I.

9. Effect of secondary injections of antigen upon the retention in liver of a primary injection.

10. Studies on the mechanism of hypersensitivity phenomena. II. The participation of complement in passive cutaneous anaphylaxis of the albino rat.

1. HEMOLYTIC COMPLEMENT IN SYNOVIAL FLUID.

2. THE ACTION OF SOLUBLE ANTIGEN--ANTIBODY COMPLEXES IN PERFUSED GUINEA-PIG LUNG.

3. Influence of the physical state of endotoxic preparations on dermal toxicity.

4. The effects of guinea-pig gamma globulins on capillary permeability and serum complement.

5. A permeability factor released from guinea-pig serum by antigen-antibody precipitates.

6. Complement-dependent anaphylactic reactions.

7. Investigations of Allergic Liver Injury: I. Light, Fluorescent and Electron Microscopic Study of the Effects of Soluble Immune Aggregates.

8. Comparison of intravenous gamma globulin and a monoclonal anti-Fc receptor antibody as inhibitors of immune clearance in vivo in mice.

9. Immunohistochemical study of arteriolar (simple) hyalinosis in spleen.

10. Pan- and auto-agglutination in albumin: a serological and immunochemical study of five cases.