Literature DB >> 1361926

[Ammonium bituminosulfonate (Ichthyol). Anti-inflammatory effect and inhibition of the 5-lipoxygenase enzyme].

W Diezel1, T Schewe, E Rohde, T Rosenbach, B M Czarnetzki.   

Abstract

Ammonium bituminosulphonate (Ichthyol) inhibits 5-lipoxygenase activity in human polymorphonuclear neutrophils. The inhibition is dose-dependent and occurs at non-cytotoxic concentrations of the drug. This results in a decreased release of Leukotriene B4 from polymorphonuclear neutrophils. Furthermore, when applied to the ear skin of AB/Bln mice pretreated with croton oil, Ichthyol reduces the inflammatory reaction.

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Year:  1992        PMID： 1361926

Source DB:  PubMed          Journal:  Hautarzt        ISSN： 0017-8470            Impact factor:   0.751


  3 in total

1.  Inhibitory effects of sulfonated shale oils (ammonium bituminosulphonates, Ichthyols) on enzymes of polyenoic fatty acid metabolism.

Authors:  C Schewe; T Schewe; E Rohde; W Diezel; B M Czarnetzki
Journal:  Arch Dermatol Res       Date:  1994       Impact factor: 3.017

2.  Clinical and Videodermoscopic Evaluation of the Efficacy, Safety, and Tolerability of a Shampoo Containing Ichthyol, Zanthalene, Mandelic Acid, and Honey in the Treatment of Scalp Psoriasis.

Authors:  Maria Mariano; Maria Pia De Padova; Sandra Lorenzi; Norma Cameli
Journal:  Skin Appendage Disord       Date:  2018-02-16

3.  Sodium Bituminosulfonate Used to Treat Rosacea Modulates Generation of Inflammatory Mediators by Primary Human Neutrophils.

Authors:  Susanne Schiffmann; Sandra Gunne; Marina Henke; Thomas Ulshöfer; Dieter Steinhilber; Annette Sethmann; Michael J Parnham
Journal:  J Inflamm Res       Date:  2021-06-16
  3 in total

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