Literature DB >> 1361916

Calcium channel blocking agents and potassium-stimulated release of glutamate from cerebellar slices.

B G Dickie1, J A Davies.   

Abstract

The effects of calcium channel blockers and tetrodotoxin on the potassium-stimulated release of endogenous glutamate from rat cerebellar slices was assessed. Verapamil (10 microM), omega-conotoxin (1 and 10 microM) and cobalt (2 mM) all significantly decreased release. Amiloride (100 microM) and tetrodotoxin (0.5 and 1 microM) had no effect. The results suggest a role for N-type voltage-operated calcium channels in the potassium-stimulated release of glutamate.

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Year:  1992        PMID： 1361916     DOI： 10.1016/0014-2999(92)90291-b

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Potassium channel activators decrease endogenous glutamate release from rat cerebellar slices.

Authors:  B G Dickie; J A Davies
Journal:  Amino Acids       Date:  1995-06       Impact factor: 3.520

2.  The anticonvulsant effects of the enantiomers of losigamone.

Authors:  F A Jones; J A Davies
Journal:  Br J Pharmacol       Date:  1999-11       Impact factor: 8.739

3.  The effect of the desglycinyl metabolite of remacemide hydrochloride (FPL 12495AA) and dizocilpine (MK-801) on endogenous amino acid release from mouse cortex.

Authors:  J Srinivasan; A Richens; J A Davies
Journal:  Br J Pharmacol       Date:  1995-12       Impact factor: 8.739

4.  The effects of sigma ligands on the release of glutamate from rat striatal slices.

Authors:  Y Ellis; J A Davies
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-08       Impact factor: 3.000

5.  Differential modulation of synaptic transmission by calcium chelators in young and aged hippocampal CA1 neurons: evidence for altered calcium homeostasis in aging.

Authors:  A Ouanounou; L Zhang; M P Charlton; P L Carlen
Journal:  J Neurosci       Date:  1999-02-01       Impact factor: 6.167

6.  Glutamate efflux from rat brain slices and cultures: a comparison of the depolarizing agents potassium, 4-aminopyridine, and veratrine.

Authors:  T A Patterson; E K Kim; M J Meldrum; R Dawson
Journal:  Neurochem Res       Date:  1995-02       Impact factor: 3.996
  6 in total

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