Literature DB >> 13618543

The effect of some oximes in sarin poisoning.

J P RUTLAND.   

Abstract

The effects of monoisonitrosoacetone (MINA), diacetylmonoxime (DAM) and pyridine-2-aldoxime methiodide (P2AM) upon the cholinesterase of sarin poisoned rats have been studied. Monoisonitrosoacetone and diacetylmonoxime given before sarin protected blood and brain cholinesterase from inhibition. Monoisonitrosoacetone given after the appearance of signs of poisoning caused a rapid reactivation of brain cholinesterase. Diacetylmonoxime, at an equimolar dose, produced only a slight increase in enzyme activity, and pyridine-2-aldoxime methiodide, the best reactivator in vitro, reactivated blood but not brain cholinesterase. There is a relationship between protection and reactivation of brain cholinesterase and prevention and alleviation of signs of poisoning.

Entities:  

Keywords:  CHOLINESTERASE/antagonists; HYDROXYLAMINES/effects; PHOSPHATES/poisoning

Mesh：

Substances：

Year:  1958        PMID： 13618543      PMCID： PMC1481866          DOI： 10.1111/j.1476-5381.1958.tb00228.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  6 in total

1.  The reactivation by oximes and hydroxamic acids of cholinesterase inhibited by organo-phosphorus compounds.

Authors:  A F CHILDS; D R DAVIES; A L GREEN; J P RUTLAND
Journal:  Br J Pharmacol Chemother       Date:  1955-12

2.  The cerebral distributions of a tertiary and a quaternary anticholinesterase agent following intravenous and intraventricular injection.

Authors:  G B KOELLE; E C STEINER
Journal:  J Pharmacol Exp Ther       Date:  1956-12       Impact factor: 4.030

3.  The nature of the toxicity of 2-oxo-oximes.

Authors:  B M ASKEW; D R DAVIES; A L GREEN; R HOLMES
Journal:  Br J Pharmacol Chemother       Date:  1956-12

4.  Oximes and hydroxamic acids as antidotes in anticholinesterase poisoning.

Authors:  B M ASKEW
Journal:  Br J Pharmacol Chemother       Date:  1956-12

5.  The location of cholinesterase in the central nervous system.

Authors:  A S V BURGEN; L M CHIPMAN
Journal:  Q J Exp Physiol Cogn Med Sci       Date:  1952

6.  Return of cholinesterase activity in the rat after inhibition by organophosphorus compounds. I. Diethyl p-nitro-phenyl phosphate (E 600, paraoxon).

Authors:  A N DAVISON
Journal:  Biochem J       Date:  1953-07       Impact factor: 3.857
  6 in total
  10 in total

1.  The inhibition of acetylcholinesterase by organophosphorus compounds and its reversal.

Authors:  F HOBBIGER
Journal:  Proc R Soc Med       Date:  1961-05

2.  Blood concentrations of 2,3-butanedione monoxime and some blood biochemical changes in Bubalus bubalis after intramuscular administration of this cholinesterase reactivator.

Authors:  J K Malik; A K Srivastava
Journal:  Vet Res Commun       Date:  1987       Impact factor: 2.459

3.  Proceedings of the British Pharmacological Society. 17th-19th December, 1979: University of London (Institute of Education).

Authors: 
Journal:  Br J Pharmacol       Date:  1980-06       Impact factor: 8.739

4.  A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides.

Authors:  Christina M Wilhelm; Thomas H Snider; Michael C Babin; David A Jett; Gennady E Platoff; David T Yeung
Journal:  Toxicol Appl Pharmacol       Date:  2014-10-31       Impact factor: 4.219

5.  Oximes of alpha omega-diquaternary alkane salts as antidotes to organophosphate anticholinesterases.

Authors:  W K BERRY; D R DAVIES; A L GREEN
Journal:  Br J Pharmacol Chemother       Date:  1959-06

6.  Protection against lethal organophosphate poisoning by quaternary pyridine aldoximes.

Authors:  F HOBBIGER; P W SADLER
Journal:  Br J Pharmacol Chemother       Date:  1959-06

7.  The effects of intracisternal sarin and pyridine-2-aldoxime methyl methanesulphonate in anesthetized dogs.

Authors:  R V BROWN
Journal:  Br J Pharmacol Chemother       Date:  1960-03

8.  Treatment with tertiary oximes prevents seizures and improves survival following sarin intoxication.

Authors:  Tsung-Ming Shih; Jacob W Skovira; John C O'Donnell; John H McDonough
Journal:  J Mol Neurosci       Date:  2009-08-13       Impact factor: 3.444

9.  Protection against diisopropylfluorophosphate intoxication by pyridostigmine and physostigmine in combination with atropine and mecamylamine.

Authors:  L Harris; D Stitcher
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-08       Impact factor: 3.000

10.  Discovery of Novel Non-Oxime Reactivators Showing In Vivo Antidotal Efficiency for Sarin Poisoned Mice.

Authors:  Zhao Wei; Xinlei Zhang; Huifang Nie; Lin Yao; Yanqin Liu; Zhibing Zheng; Qin Ouyang
Journal:  Molecules       Date:  2022-02-07       Impact factor: 4.411
  10 in total

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