Literature DB >> 1361126

T cells and eosinophils in the pathogenesis of asthma.

C J Corrigan1, A B Kay.   

Abstract

Persistent asthma is characterized by chronic inflammation of the bronchial mucosa, where T cells and eosinophils are prominent. This article summarizes the evidence that asthmatic bronchial inflammation is initiated and propagated by cytokines secreted by activated T cells and other cells, and describes how the release of specific cytokines could result in local preferential accumulation and activation of eosinophils.

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Year:  1992        PMID： 1361126     DOI： 10.1016/0167-5699(92)90026-4

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  88 in total

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8.  Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma.

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9.  Role of metalloelastase in a model of allergic lung responses induced by cockroach allergen.

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10.  Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity.

Authors:  B F DiCosmo; G P Geba; D Picarella; J A Elias; J A Rankin; B R Stripp; J A Whitsett; R A Flavell
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