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Literature DB >> 13611163

Identification of a toxic cellular component of group A streptococci as a complex of group-specific C polysaccharide and a protein.

J H SCHWAB, W J CROMARTIE, B S ROBERSON.

Abstract

The toxic cellular component of Group A streptococci, which produces a chronic multinodular lesion of the dermal connective tissue of rabbits, has been isolated by means of differential centrifugation and electrophoresis. The substance appeared to be a macromolecular complex of polysaccharide and protein, the polysaccharide having the serological and chemical characteristics of the group-specific C substance. Evidence is presented indicating that the polysaccharide moiety is an essential part of the toxic complex. It is suggested that further studies of this material may help elucidate the mechanism of tissue damage in the non-suppurative sequelae of Group A streptococcal infections.

Entities: Chemical Disease Species

Keywords: POLYSACCHARIDES; PROTEINS; STREPTOCOCCUS

Mesh：

Substances：

Year: 1959 PMID： 13611163 PMCID： PMC2136929 DOI： 10.1084/jem.109.1.43

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

11 in total

1. Studies of streptococcal cell walls. I. Isolation, chemical composition, and preparation of M protein.

Authors: S S BARKULIS; M F JONES
Journal: J Bacteriol Date: 1957-08 Impact factor: 3.490

2. Studies on a toxic cellular component of group A streptococci.

Authors: J H SCHWAB; W J CROMARTIE
Journal: J Bacteriol Date: 1957-11 Impact factor: 3.490

3. A simple ultraviolet spectrophotometric method for the determination of protein.

Authors: W J WADDELL
Journal: J Lab Clin Med Date: 1956-08

4. Localization of enzymes in the microbial cell.

Authors: M ALEXANDER
Journal: Bacteriol Rev Date: 1956-06

5. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors: K BURTON
Journal: Biochem J Date: 1956-02 Impact factor: 3.857

6. A new micromethod for the determination of total lipids in serum.

Authors: B SWAHN
Journal: Scand J Clin Lab Invest Date: 1952 Impact factor: 1.713

7. The significance of antigen in animal tissues.

Authors: L D FELTON
Journal: J Immunol Date: 1949-01 Impact factor: 5.422

8. The estimation of glycogen with the anthrone reagent.

Authors: S SEIFTER; S DAYTON
Journal: Arch Biochem Date: 1950-01

9. The lysis of group A hemolytic streptococci by extracellular enzymes of Streptomyces albus. II. Nature of the cellular substrate attacked by the lytic enzymes.

Authors: M MCCARTY
Journal: J Exp Med Date: 1952-12 Impact factor: 14.307

10. Group A streptococcus polysaccharide: studies on its preparation, chemical composition, and cellular localization after intravenous injection into mice.

Authors: W C SCHMIDT
Journal: J Exp Med Date: 1952-01 Impact factor: 14.307

21 in total

Review 4. M proteins of group A streptococci.

Authors: E N Fox
Journal: Bacteriol Rev Date: 1974-03

5. Effect of nitrogen mustard, 6-mercaptopurine and cortisone on reactions of dermal connective tissue of rabbits to the streptococcal cell wall.

Authors: J H Schwab
Journal: Am J Pathol Date: 1965-10 Impact factor: 4.307

6. Biological properties of streptococcal cell-wall particles. 3. Dermonecrotic reaction to cell-wall mucopeptides.

Authors: E M Abdulla; J H Schwab
Journal: J Bacteriol Date: 1966-01 Impact factor: 3.490

7. Biological properties of streptococcal cell-wall particles. II. Purification by density gradient column electrophoresis.

Authors: J H Schwab
Journal: J Bacteriol Date: 1965-11 Impact factor: 3.490