Literature DB >> 1360841

A model of the adrenergic beta-2 receptor and binding sites for agonist and antagonist.

X Q Lewell1.   

Abstract

From the known experimental data on adrenergic ligands and beta-2 receptor a model for the ligand binding sites was proposed and built. Agonist and antagonist have overlapping but different binding sites. The model correlates well with the structural information known from a series of adrenergic ligands.

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Year:  1992        PMID： 1360841

Source DB:  PubMed          Journal:  Drug Des Discov        ISSN： 1026-7921


  9 in total

1.  Modeling and docking the endothelin G-protein-coupled receptor.

Authors:  A J Orry; B A Wallace
Journal:  Biophys J       Date:  2000-12       Impact factor: 4.033

2.  A sequence and structural study of transmembrane helices.

Authors:  R P Bywater; D Thomas; G Vriend
Journal:  J Comput Aided Mol Des       Date:  2001-06       Impact factor: 3.686

3.  Extent of salmeterol-mediated reassertion of relaxation in guinea-pig trachea pretreated with aliphatic side chain structural analogues.

Authors:  A Bergendal; A Lindén; B E Skoogh; M Gerspacher; G P Anderson; C G Löfdahl
Journal:  Br J Pharmacol       Date:  1996-03       Impact factor: 8.739

4.  A computer modeling postulated mechanism for angiotensin II receptor activation.

Authors:  M P Joseph; B Maigret; J C Bonnafous; J Marie; H A Scheraga
Journal:  J Protein Chem       Date:  1995-07

5.  Automated method for modeling seven-helix transmembrane receptors from experimental data.

Authors:  P Herzyk; R E Hubbard
Journal:  Biophys J       Date:  1995-12       Impact factor: 4.033

6.  Molecular modeling of adenosine receptors. The ligand binding site on the rat adenosine A2A receptor.

Authors:  A P IJzerman; E M van der Wenden; P J van Galen; K A Jacobson
Journal:  Eur J Pharmacol       Date:  1994-06-15       Impact factor: 4.432

7.  Modelling and mutation studies on the histamine H1-receptor agonist binding site reveal different binding modes for H1-agonists: Asp116 (TM3) has a constitutive role in receptor stimulation.

Authors:  A M ter Laak; H Timmerman; R Leurs; P H Nederkoorn; M J Smit; G M Donné-Op den Kelder
Journal:  J Comput Aided Mol Des       Date:  1995-08       Impact factor: 3.686

8.  Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor.

Authors:  K Wieland; H M Zuurmond; C Krasel; A P Ijzerman; M J Lohse
Journal:  Proc Natl Acad Sci U S A       Date:  1996-08-20       Impact factor: 11.205

9.  A strategy using NMR peptide structures of thromboxane A2 receptor as templates to construct ligand-recognition pocket of prostacyclin receptor.

Authors:  Cheng-Huai Ruan; Jaixin Wu; Ke-He Ruan
Journal:  BMC Biochem       Date:  2005-11-04       Impact factor: 4.059
  9 in total

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