Determination of the rate of cerebral oxygen consumption and regional cerebral blood flow by non-invasive 17O in vivo NMR spectroscopy and magnetic resonance imaging: Part 1. Theory and data analysis methods.

Theory and novel data analysis methods of 17O inhalation measurements are presented for the calculation of CMRO2, regional cerebral blood flow (rCBF), the reflow (R), the arterial venous difference (AVD) and the partition coefficient (lambda). Several of the methods proposed for the determination of CMRO2 do not require measurements of regional cerebral blood flow and H2(17)O arterial concentration. All methods of analysis are based on the Kety-Schmidt approach.