Literature DB >> 1360516

Microsomal formation of N-benzyl-4-hydroxymethylaniline from N-benzyl-4-methylaniline.

M Ulgen1, J W Gorrod.   

Abstract

The in-vitro metabolism of N-benzyl-4-methylaniline was re-examined using male hamster and rabbit hepatic microsomes; both species generated N-benzyl-4-hydroxymethylaniline, confirmed by TLC and HPLC, comparison with authentic compound. Further confirmation of the formation of this metabolite was achieved by use of a rapid scan UV detector.

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Year:  1992        PMID: 1360516     DOI: 10.1111/j.2042-7158.1992.tb03222.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN: 0022-3573            Impact factor:   3.765


  1 in total

1.  In vitro microsomal metabolism of nuclear chloro substituted secondary amines and imines.

Authors:  I Küçükgüzel; M Ulgen; J W Gorrod
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1997 Oct-Dec       Impact factor: 2.441

  1 in total

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