| Literature DB >> 1360409 |
N Kioka1, Y Yamano, T Komano, K Ueda.
Abstract
The MDR1 gene, considered to be involved in multidrug resistance of cancer cells, is expressed in liver, kidney, small intestine and the blood-brain barrier. We investigated MDR1 gene expression in the well-differentiated hepatoma cell line HepG2 after exposure to several stresses and found that sodium arsenite treatment increased MDR1 gene expression 2.6-fold. Deletion analysis of the MDR1 promoter indicated that the transcriptional activation after exposure to arsenite depends on a 60-bp region containing two heat-shock responsive elements.Entities:
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Year: 1992 PMID： 1360409 DOI： 10.1016/0014-5793(92)80205-u
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124