Literature DB >> 13602795

Demethylation of chlorpromazine-(N-methyl)-C14.

J J ROSS, R L YOUNG, A R MAASS.   

Abstract

Chlorpromazine methyl-C(14) was administered to three groups of rats-orally to one group following chronic oral administration of the unlabeled drug; orally to an unprimed group; and intravenously to another unprimed group. Appearance of C(14)O(2) in the air expired by all animals indicated that the rat metabolized the side chain of the labeled drug.

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Keywords:  CHLORPROMAZINE/metabolism

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Year:  1958        PMID: 13602795     DOI: 10.1126/science.128.3334.1279

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  1 in total

1.  Perazine, chlorpromazine and imipramine as inducers of microsomal drug metabolism.

Authors:  U Breyer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

  1 in total

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