Literature DB >> 1359976

Visualization of dopamine D3-like receptors in human brain with [125I]epidepride.

A M Murray1, H Ryoo, J N Joyce.   

Abstract

In sections of human brain containing the striatum (caudate, nucleus, putamen, nucleus accumbens) the competition for binding of [125I]epidepride by compounds with differing selectivity for dopamine D2 and D3 receptors was examined. Domperidone showed higher affinity for D2-like than D3-like sites whereas 7-OH-DPAT (7-hydroxy-2-(N,N-di-n-propylamino)tetralin) and quinpirole demonstrated the reverse selectivity. The pattern of [125I]epidepride binding in the presence of a high concentration of domperidone was negligible in the dorsal striatum but indicated islands of dense binding to D3-like receptors in the nucleus accumbens and ventral putamen.

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Year:  1992        PMID： 1359976     DOI： 10.1016/0922-4106(92)90164-q

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  A single photon emission computed tomography scan study of striatal dopamine D2 receptor binding with 123I-epidepride in patients with schizophrenia and controls.

Authors:  P Tibbo; P H Silverstone; A J McEwan; J Scott; A Joshua; K Golberg
Journal:  J Psychiatry Neurosci       Date:  1997-01       Impact factor: 6.186

2.  Upregulation of (+)-7-hydroxy-N,N-di-n-[3H]propyl-2-aminotetralin binding following intracerebroventricular administration of a nitric oxide generator.

Authors:  D R Wallace; R M Booze
Journal:  Neurochem Res       Date:  1997-02       Impact factor: 3.996

3.  Endogenous dopamine limits the binding of antipsychotic drugs to D3 receptors in the rat brain: a quantitative autoradiographic study.

Authors:  A Schotte; P F Janssen; P Bonaventure; J E Leysen
Journal:  Histochem J       Date:  1996-11

4.  Localization of dopamine D3 receptors to mesolimbic and D2 receptors to mesostriatal regions of human forebrain.

Authors:  A M Murray; H L Ryoo; E Gurevich; J N Joyce
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-08       Impact factor: 11.205

5.  Behavioural effects in the rat of the putative dopamine D3 receptor agonist 7-OH-DPAT: comparison with quinpirole and apomorphine.

Authors:  R Depoortere; G Perrault; D J Sanger
Journal:  Psychopharmacology (Berl)       Date:  1996-04       Impact factor: 4.530

Review 6.  The potential role of dopamine D₃ receptor neurotransmission in cognition.

Authors:  Shinichiro Nakajima; Philip Gerretsen; Hiroyoshi Takeuchi; Fernando Caravaggio; Tiffany Chow; Bernard Le Foll; Benoit Mulsant; Bruce Pollock; Ariel Graff-Guerrero
Journal:  Eur Neuropsychopharmacol       Date:  2013-06-20       Impact factor: 4.600

7.  Dopamine D1, D2, D3 receptors, vesicular monoamine transporter type-2 (VMAT2) and dopamine transporter (DAT) densities in aged human brain.

Authors:  Jianjun Sun; Jinbin Xu; Nigel J Cairns; Joel S Perlmutter; Robert H Mach
Journal:  PLoS One       Date:  2012-11-21       Impact factor: 3.240
  7 in total

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