Literature DB >> 1359428

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.

P Mombaerts1, A R Clarke, M A Rudnicki, J Iacomini, S Itohara, J J Lafaille, L Wang, Y Ichikawa, R Jaenisch, M L Hooper.   

Abstract

Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-beta gene rearrangement or expression is critical for the differentiation of CD4-CD8- thymocytes to CD4+CD8+ thymocytes, as well as for the expansion of the pool of CD4+CD8+ cells. TCR-alpha is irrelevant in these developmental processes. The development of gamma delta T cells does not depend on either TCR-alpha or TCR-beta.

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Year:  1992        PMID： 1359428     DOI： 10.1038/360225a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  337 in total

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Review 2.  Receptor selection in B and T lymphocytes.

Authors:  D Nemazee
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3.  Basal metabolic rate and the evolution of the adaptive immune system.

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4.  T cell-specific FADD-deficient mice: FADD is required for early T cell development.

Authors:  N H Kabra; C Kang; L C Hsing; J Zhang; A Winoto
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-15       Impact factor: 11.205

5.  The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling.

Authors:  A M Cheng; I Negishi; S J Anderson; A C Chan; J Bolen; D Y Loh; T Pawson
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

Review 6.  Insights into T-cell development from studies using transgenic and knockout mice.

Authors:  M A Basson; R Zamoyska
Journal:  Mol Biotechnol       Date:  2001-05       Impact factor: 2.695

7.  T lymphocyte immunity in host defence against Chlamydia trachomatis and its implication for vaccine development.

Authors:  X Yang; R Brunham
Journal:  Can J Infect Dis       Date:  1998-03

8.  Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice.

Authors:  Rima Elhage; Pierre Gourdy; Laurent Brouchet; Jacek Jawien; Marie-José Fouque; Catherine Fiévet; Xavier Huc; Yara Barreira; Jean Claude Couloumiers; Jean-François Arnal; Francis Bayard
Journal:  Am J Pathol       Date:  2004-12       Impact factor: 4.307

9.  The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.

Authors:  Sarah A Sullivan; Minghua Zhu; Steven Bao; Catherine A Lewis; Chih-wen Ou-Yang; Weiguo Zhang
Journal:  J Immunol       Date:  2014-02-12       Impact factor: 5.422

10.  Susceptibility of T cell receptor-alpha chain knock-out mice to ultraviolet B light and fluorouracil: a novel model for drug-induced cutaneous lupus erythematosus.

Authors:  T Yoshimasu; T Nishide; N Seo; A Hiroi; T Ohtani; K Uede; F Furukawa
Journal:  Clin Exp Immunol       Date:  2004-05       Impact factor: 4.330
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