| Literature DB >> 1359066 |
M Sansone1, F Pavone, M Battaglia, W Daniel, J Vetulani.
Abstract
Nifedipine, a dihydropyridine calcium channel blocker, and hydralazine, a non-calcium channel antagonist vasodilatator, enhanced pentobarbitone-induced sleeping time and reversed locomotor hyperactivity induced by a subhypnotic dose of the barbiturate in mice. The similarity of the behavioural effects, exerted by nifedipine and hydralazine, suggest that haemodynamic factors may play an important role in the interaction of calcium channel antagonists with barbiturates.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1359066 DOI： 10.1111/j.2042-7158.1992.tb03645.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765