Literature DB >> 1358798

Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5.

D Sieburth1, E W Jabs, J A Warrington, X Li, J Lasota, S LaForgia, K Kelleher, K Huebner, J J Wasmuth, S F Wolf.   

Abstract

IL12 (formerly NKSF or CLMF) is a unique cytokine composed of two unrelated disulfide-linked subunits. The larger 40-kDa subunit (p40) is a member of the cytokine receptor family, and the smaller 35-kDa subunit (p35) is related to IL6 and GCSF. The chromosomal localization of these two subunits was determined by PCR analysis of DNA from rodent-human hybrids. More refined mapping was obtained by PCR analysis of hybrids containing translocation chromosomes and for p40, by analysis of radiation hybrids. The subunits map to different chromosomes: p40 (IL12B) to 5q31-q33 and p35 (IL12A) to 3p12-3q13.2.

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Year:  1992        PMID： 1358798     DOI： 10.1016/s0888-7543(05)80283-6

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  31 in total

1.  Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression.

Authors:  Jianguo Liu; Shanjin Cao; Sunjung Kim; Elaine Y Chung; Yoichiro Homma; Xiuqin Guan; Violeta Jimenez; Xiaojing Ma
Journal:  Curr Immunol Rev       Date:  2005-06

2.  Contribution of IL12A and IL12B polymorphisms to the risk of cervical cancer.

Authors:  Andrzej Roszak; Adrianna Mostowska; Anna Sowińska; Margarita Lianeri; Pawel P Jagodziński
Journal:  Pathol Oncol Res       Date:  2012-05-22       Impact factor: 3.201

3.  Sepsis and pathophysiology of anthrax in a nonhuman primate model.

Authors:  Deborah J Stearns-Kurosawa; Florea Lupu; Fletcher B Taylor; Gary Kinasewitz; Shinichiro Kurosawa
Journal:  Am J Pathol       Date:  2006-08       Impact factor: 4.307

4.  The interleukin-12 beta subunit (p40) maps to mouse chromosome 11.

Authors:  N Noben-Trauth; P A Schweitzer; K R Johnson; S F Wolf; B B Knowles; L D Shultz
Journal:  Mamm Genome       Date:  1996-05       Impact factor: 2.957

5.  Genetic mapping of the IL-12 alpha chain gene (Il12a) on mouse chromosome 3.

Authors:  P A Schweitzer; N Noben-Trauth; S C Pelsue; K R Johnson; S F Wolf; L D Shultz
Journal:  Mamm Genome       Date:  1996-05       Impact factor: 2.957

6.  Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q.

Authors:  M K Wirtz; J R Samples; P L Kramer; K Rust; J R Topinka; J Yount; R D Koler; T S Acott
Journal:  Am J Hum Genet       Date:  1997-02       Impact factor: 11.025

7.  Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults.

Authors:  Chintana Phawong; Collins Ouma; Piyatida Tangteerawatana; Jarinee Thongshoob; Tom Were; Yuvadee Mahakunkijcharoen; Duangrurdee Wattanasirichaigoon; Douglas Jay Perkins; Srisin Khusmith
Journal:  Immunogenetics       Date:  2010-04-13       Impact factor: 2.846

Review 8.  Interleukin-12: a bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency.

Authors:  J Chehimi; G Trinchieri
Journal:  J Clin Immunol       Date:  1994-05       Impact factor: 8.317

Review 9.  The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases.

Authors:  Christoph Hölscher
Journal:  Med Microbiol Immunol       Date:  2003-06-27       Impact factor: 3.402

10.  The anergic state in sarcoidosis is associated with diminished dendritic cell function.

Authors:  Sneha Mathew; Kristy L Bauer; Arne Fischoeder; Nina Bhardwaj; Stephen J Oliver
Journal:  J Immunol       Date:  2008-07-01       Impact factor: 5.422
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