| Literature DB >> 13584739 |
Abstract
Local tetanus was induced in rabbits by the intramuscular injection of tetanus toxin. The relative potency of drugs which abolished the muscle spasm was determined using quantitative electromyography and the accuracy of the method tested with mephenesin and thiopentone. It is suggested that the method is suitable for screening new drugs for clinical use.Entities:
Keywords: MEPHENESIN/effects; TETANUS/experimental; THIOPENTAL/effects
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Year: 1958 PMID： 13584739 PMCID： PMC1481772 DOI： 10.1111/j.1476-5381.1958.tb00913.x
Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826