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Literature DB >> 13584737

The effect of substance P on the peristaltic reflex of the isolated guinea-pig ileum.

Abstract

The introduction of substance P into the lumen of the isolated guinea-pig ileum caused an increase in the number and amplitude of the peristaltic waves. In preparations in which the peristaltic reflex was abolished, by fatigue, by external or internal application of 5-hydroxytryptamine, or by lowering the temperature of the bath, the introduction of substance P into the lumen of the intestine restored peristalsis. This effect of substance P was absent in preparations in which the mucous membrane was removed. Hexamethonium abolished the effect of substance P on peristalsis. It is concluded that substance P acts on the afferent nervous elements of the peristaltic reflex arc, possibly on the sensory receptors.

Entities: Chemical Disease Species

Keywords: CENTRAL NERVOUS SYSTEM/physiology; INTESTINES/physiology; MUSCLES/physiology

Mesh：

Substances：
Serotonin
Substance P

Year: 1958 PMID： 13584737 PMCID： PMC1481771 DOI： 10.1111/j.1476-5381.1958.tb00911.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

10 in total

1. [Studies on the production of afferent impulses].

Authors: F LEMBECK
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1957

2. The action of lysergic acid diethylamide (LSD 25), its 2-brom derivative (BOL 148) and of 5-hydroxytryptamine (5-HT) on the peristaltic reflex of the guinea-pig ileum.

Authors: K H GINZEL
Journal: J Physiol Date: 1957-07-11 Impact factor: 5.182

3. Inhibition of the peristaltic reflex of the isolated guinea-pig ileum.

Authors: H W KOSTERLITZ; J A ROBINSON
Journal: J Physiol Date: 1957-04-30 Impact factor: 5.182

4. An investigation of the peristaltic reflex in relation to anatomical observations.

Authors: E BULBRING; R C LIN; G SCHOFIELD
Journal: Q J Exp Physiol Cogn Med Sci Date: 1958-01

5. An evaluation of the action of substance P on the jejunum of the rabbit.

Authors: M R BLAIR; B B CLARK
Journal: J Pharmacol Exp Ther Date: 1956-08 Impact factor: 4.030

6. On the occurrence of substance P in the rectosigmoid in Hirschsprung's disease.

Authors: T EHRENPREIS; B PERNOW
Journal: Acta Physiol Scand Date: 1953-02-28

7. An outflow recorder useful for detecting small amounts of vasopressin.

Authors: R P Stephenson
Journal: J Physiol Date: 1948-03-15 Impact factor: 5.182

8. Catechol amines and substance P in the mammalian eye.

Authors: H DUNER; U S VON EULER; B PERNOW
Journal: Acta Physiol Scand Date: 1954-07-18

9. Distribution of histamine and substance P in the wall of the dog's digestive tract.

Authors: W W DOUGLAS; W FELDBERG; W D M PATON; M SCHACHTER
Journal: J Physiol Date: 1951-10-29 Impact factor: 5.182

10. The effect of cooling and of 5-hydroxytryptamine on the peristaltic reflex of the isolated guinea-pig ileum.

Authors: D BELESLIN; V VARAGIC
Journal: Br J Pharmacol Chemother Date: 1958-09

10 in total

8 in total

The effect of substance P on the peristaltic reflex of the isolated guinea-pig ileum.

1. [Studies on the production of afferent impulses].

2. The action of lysergic acid diethylamide (LSD 25), its 2-brom derivative (BOL 148) and of 5-hydroxytryptamine (5-HT) on the peristaltic reflex of the guinea-pig ileum.

3. Inhibition of the peristaltic reflex of the isolated guinea-pig ileum.

4. An investigation of the peristaltic reflex in relation to anatomical observations.

5. An evaluation of the action of substance P on the jejunum of the rabbit.

6. On the occurrence of substance P in the rectosigmoid in Hirschsprung's disease.

7. An outflow recorder useful for detecting small amounts of vasopressin.

8. Catechol amines and substance P in the mammalian eye.

9. Distribution of histamine and substance P in the wall of the dog's digestive tract.

10. The effect of cooling and of 5-hydroxytryptamine on the peristaltic reflex of the isolated guinea-pig ileum.

1. The action of eledoisin on the peristaltic reflex of guinea-pig isolated ileum.

2. The effect of angiotensin on the peristaltic reflex of the isolated guinea-pig ileum.

3. On the ability of caerulein to increase propulsive activity in the isolated small and large intestine.

4. An improved method for studying the peristaltic reflex in the isolated colon.

5. Effect of substance P on opossum duodenal smooth muscle.

6. Effect of neuropeptides on the efficiency of the peristaltic reflex.

7. The effect of substance P on the superior cervical ganglion of the cat.

8. An analysis of possible nervous mechanisms involved in the peristaltic reflex.