| Literature DB >> 1358400 |
C Shin1, Y Tamaki, J T Wilson, L Butler, T Sakaguchi.
Abstract
Extracellular field recordings were made in CA1 in the hippocampal explant cultures in oxygenated artificial cerebrospinal fluid. Schaffer collaterals were stimulated with 1-s trains of 60 Hz pulses every 10 min. Seizures were reliably elicited with progressive lengthening over 1-2 h. D-APV, an N-methyl-D-aspartate (NMDA) antagonist, stereoselectively blocked the development of seizures. Thus we have demonstrated that in vitro epileptogenesis occurs in hippocampal explant cultures through NMDA receptor mediated mechanisms.Entities:
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Year: 1992 PMID： 1358400 DOI： 10.1016/0006-8993(92)91171-a
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252