OBJECTIVE: To clarify the association between primary hyperparathyroidism and cortical osteopenia. DESIGN: Open study. SETTING: Department of Surgery, University of Lund, Sweden. SUBJECTS: 38 patients with primary hyperparathyroidism. OUTCOME MEASURES: Correlation between bone density (measured by single photon absorption) and age; sex; serum concentrations of parathyroid hormone and ionised calcium; serum alkaline phosphatase activity; and serum concentration of calcium, phosphate, creatinine, urea, osteocalcin, 25 hydroxycholecalciferol, and 1,25 dihydroxycholecalciferol. RESULTS: There was no difference in bone density between men and women. There was no correlation between bone density and severity of hypercalcaemia or age. No biochemical abnormality was peculiar to the seven patients whose bone density was more than two SD below the population mean. Serum concentrations of 1,25 dihydroxycholecalciferol and osteocalcin both correlated significantly with bone density (p < 0.05) and there was a strong correlation between serum osteocalcin and serum intact parathyroid hormone (p < 0.001). Serum osteocalcin had the strongest correlation with bone density of any of the biochemical variables. CONCLUSION: There is little association between bone density and serum concentration of parathyroid hormone.
OBJECTIVE: To clarify the association between primary hyperparathyroidism and cortical osteopenia. DESIGN: Open study. SETTING: Department of Surgery, University of Lund, Sweden. SUBJECTS: 38 patients with primary hyperparathyroidism. OUTCOME MEASURES: Correlation between bone density (measured by single photon absorption) and age; sex; serum concentrations of parathyroid hormone and ionised calcium; serum alkaline phosphatase activity; and serum concentration of calcium, phosphate, creatinine, urea, osteocalcin, 25 hydroxycholecalciferol, and 1,25 dihydroxycholecalciferol. RESULTS: There was no difference in bone density between men and women. There was no correlation between bone density and severity of hypercalcaemia or age. No biochemical abnormality was peculiar to the seven patients whose bone density was more than two SD below the population mean. Serum concentrations of 1,25 dihydroxycholecalciferol and osteocalcin both correlated significantly with bone density (p < 0.05) and there was a strong correlation between serum osteocalcin and serum intact parathyroid hormone (p < 0.001). Serum osteocalcin had the strongest correlation with bone density of any of the biochemical variables. CONCLUSION: There is little association between bone density and serum concentration of parathyroid hormone.
Authors: Erik Nordenström; Johan Westerdahl; Birger Lindergård; Pia Lindblom; Anders Bergenfelz Journal: World J Surg Date: 2002-09-26 Impact factor: 3.352
Authors: Antonio Sitges-Serra; Meritxell Girvent; José A Pereira; Jaime Jimeno; Xavier Nogués; Francisco J Cano; Joan J Sancho Journal: World J Surg Date: 2004-11 Impact factor: 3.352