Literature DB >> 1357080

Are Sinc and the PrP gene congruent? Evidence from PrP gene analysis in Sinc congenic mice.

N Hunter1, J C Dann, A D Bennett, R A Somerville, I McConnell, J Hope.   

Abstract

Congenic mouse strains VM/Dk and VM-Sincs7/Dk differ at the Sinc gene, which controls the incubation period of scrapie in mice; VM/Dk mice are Sincp7p7 and VM-Sincs7/Dk mice are Sincs7s7. Restriction fragment length polymorphism and DNA sequencing analysis demonstrated that the PrP genes also differ in these strains, confirming the close genetic linkage of Sinc and PrP. Using the restriction enzyme HhaI, we have shown that at least 100 kb of DNA flanking the PrP gene differs between the two strains, and therefore the congruence of the Sinc and PrP genes is still not certain.

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Year:  1992        PMID： 1357080     DOI： 10.1099/0022-1317-73-10-2751

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  12 in total

1.  The epidemiology of BSE in cattle herds in Great Britain. I. Epidemiological processes, demography of cattle and approaches to control by culling.

Authors:  C A Donnelly; N M Ferguson; A C Ghani; M E Woolhouse; C J Watt; R M Anderson
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1997-07-29       Impact factor: 6.237

2.  Identification of multiple quantitative trait loci linked to prion disease incubation period in mice.

Authors:  S E Lloyd; O N Onwuazor; J A Beck; G Mallinson; M Farrall; P Targonski; J Collinge; E M Fisher
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-15       Impact factor: 11.205

Review 3.  The prion strain phenomenon: molecular basis and unprecedented features.

Authors:  Rodrigo Morales; Karim Abid; Claudio Soto
Journal:  Biochim Biophys Acta       Date:  2006-12-15

4.  Lack of prion transmission by sexual or parental routes in experimentally infected hamsters.

Authors:  Rodrigo Morales; Sandra Pritzkow; Ping Ping Hu; Claudia Duran-Aniotz; Claudio Soto
Journal:  Prion       Date:  2013-10-11       Impact factor: 3.931

Review 5.  Prions, beta-sheets and transmissible dementias: is there still something missing?

Authors:  P P Liberski
Journal:  Acta Neuropathol       Date:  1995       Impact factor: 17.088

6.  Characterization and polyanion-binding properties of purified recombinant prion protein.

Authors:  D B Brimacombe; A D Bennett; F S Wusteman; A C Gill; J C Dann; C J Bostock
Journal:  Biochem J       Date:  1999-09-15       Impact factor: 3.857

7.  PrP in pathology and pathogenesis in scrapie-infected mice.

Authors:  M E Bruce; P A McBride; M Jeffrey; J R Scott
Journal:  Mol Neurobiol       Date:  1994 Apr-Jun       Impact factor: 5.590

8.  Identification and characterization of a novel mouse prion gene allele.

Authors:  Sarah E Lloyd; Simon R Thompson; Jonathan A Beck; Jacqueline M Linehan; Jonathan D F Wadsworth; Sebastian Brandner; John Collinge; Elizabeth M C Fisher
Journal:  Mamm Genome       Date:  2004-05       Impact factor: 2.957

9.  Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.

Authors:  David Westaway; Sacha Genovesi; Nathalie Daude; Rebecca Brown; Agnes Lau; Inyoul Lee; Charles E Mays; Janaky Coomaraswamy; Brenda Canine; Rose Pitstick; Allen Herbst; Jing Yang; Kerry W S Ko; Gerold Schmitt-Ulms; Stephen J Dearmond; Debbie McKenzie; Leroy Hood; George A Carlson
Journal:  PLoS Pathog       Date:  2011-11-17       Impact factor: 6.823

10.  The interpretation of disease phenotypes to identify TSE strains in mice: characterisation of BSE using PrPSc distribution patterns in the brain.

Authors:  Erica Corda; Katy E Beck; Rosemary E Sallis; Christopher M Vickery; Margaret Denyer; Paul R Webb; Susan J Bellworthy; Yvonne I Spencer; Marion M Simmons; John Spiropoulos
Journal:  Vet Res       Date:  2012-12-17       Impact factor: 3.683
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