Literature DB >> 1356643

Development of a highly cardioselective ultra short-acting beta-blocker, ONO-1101.

S Iguchi1, H Iwamura, M Nishizaki, A Hayashi, K Senokuchi, K Kobayashi, K Sakaki, K Hachiya, Y Ichioka, M Kawamura.   

Abstract

A novel, highly cardioselective ultra short-acting beta-blocker, ONO-1101, has been developed for application in the emergency treatment of tachycardia and better control of heart rate in surgery. This agent is approximately nine times more potent in beta-blocking activity in vivo and eight times more cardioselective in vitro than esmolol. This beta-blocking drug has a short duration of activity, enabling rapid recovery after cessation of administration if side effects occur. It can be used safely in patients suffering from acute heart disease and represents a major therapeutic advance in the treatment of heart disease.

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Year:  1992        PMID： 1356643     DOI： 10.1248/cpb.40.1462

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  52 in total

1.  The effects of a new ultra-short-acting beta-adrenergic blocker, ONO-1101, on cardiac function during and after cardiopulmonary bypass.

Authors:  I Ahmet; N Fukushima; Y Sawa; T Masai; K Kadoba; K Kagisaki; J C Chang; T Yamaguchi; H Matsuda
Journal:  Surg Today       Date:  1999       Impact factor: 2.549

2.  Efficacy of landiolol hydrochloride for atrial fibrillation after open heart surgery.

Authors:  Hiroyuki Nishi; Taichi Sakaguchi; Shigeru Miyagawa; Yasushi Yoshikawa; Satsuki Fukushima; Shunsuke Saito; Takayoshi Ueno; Toru Kuratani; Yoshiki Sawa
Journal:  Heart Vessels       Date:  2012-06-03       Impact factor: 2.037

3.  Metoclopramide does not prolong duration of action of landiolol attenuating the hemodynamic response to induction of anesthesia and tracheal intubation.

Authors:  Satoki Inoue; Ryuichi Abe; Masahiko Kawaguchi; Hiroshi Kobayashi; Hitoshi Furuya
Journal:  J Anesth       Date:  2010-05-08       Impact factor: 2.078

4.  Evaluation of near infrared spectroscopy for detecting the β blocker-induced decrease in cerebral oxygenation during hemodilution in a swine model.

Authors:  Tadayoshi Kurita; Koji Morita; Shigehito Sato
Journal:  J Clin Monit Comput       Date:  2015-02-10       Impact factor: 2.502

5.  Effects of landiolol on the cardiovascular response during tracheal extubation.

Authors:  Tetsuro Shirasaka; Tatsuma Iwasaki; Nobuko Hosokawa; Miki Komatsu; Toshiharu Kasaba; Mayumi Takasaki
Journal:  J Anesth       Date:  2008-08-07       Impact factor: 2.078

Review 6.  Possible indications of beta-blockers in the perioperative period other than prevention of cardiac ischemia.

Authors:  Yuji Kadoi; Shigeru Saito
Journal:  J Anesth       Date:  2010-02       Impact factor: 2.078

7.  Landiolol does not enhance the effect of ischemic preconditioning in isolated rat hearts.

Authors:  Shuchun Yu; Takasumi Katoh; Hisako Okada; Hiroshi Makino; Soichiro Mimuro; Shigehito Sato
Journal:  J Anesth       Date:  2010-01-19       Impact factor: 2.078

8.  Effect of landiolol hydrochloride on suxamethonium-induced neuromuscular block.

Authors:  Takahiro Suzuki; Mayu Aono; Tomomi Isaka; Eri Miyake; Naoko Fukano; Shigeru Saeki; Setsuro Ogawa
Journal:  J Anesth       Date:  2009-05-15       Impact factor: 2.078

9.  The effect of landiolol on cerebral blood flow in patients undergoing off-pump coronary artery bypass surgery.

Authors:  Koji Goto; Satoshi Hagiwara; Seigo Hidaka; Shunsuke Yamamoto; Junya Kusaka; Norihisa Yasuda; Chihiro Shingu; Takayuki Noguchi
Journal:  J Anesth       Date:  2010-01-06       Impact factor: 2.078

10.  Effect of low-dose landiolol, an ultrashort-acting beta-blocker, on postoperative atrial fibrillation after CABG surgery.

Authors:  Hidenori Fujiwara; Masahiro Sakurai; Asako Namai; Takae Kawamura
Journal:  Gen Thorac Cardiovasc Surg       Date:  2009-03-12
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