Literature DB >> 1355967

Alcohol-preferring rats have fewer dopamine D2 receptors in the limbic system.

E Stefanini1, M Frau, M G Garau, B Garau, F Fadda, G L Gessa.   

Abstract

Dopamine D2 receptors in nucleus accumbens, olfactory tubercle and caudate nucleus of Sardinian ethanol-preferring (SP), and non-preferring (SNP) rats were compared by using [3H]YM-09151-2 binding. SP rats exhibited, in each area, lower density of D2 receptors than SNP and unselected Wistar (UW) rats. The results suggest that reduction in D2 receptors in SP rats may be relevant to their innate preference for alcohol.

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Year:  1992        PMID： 1355967

Source DB:  PubMed          Journal:  Alcohol Alcohol        ISSN： 0735-0414            Impact factor:   2.826


  22 in total

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