Literature DB >> 1355474

Synthesis of 1233A analogs and their inhibitory activity against hydroxymethylglutaryl coenzyme A synthase.

T Sunazuka1, K Tsuzuki, H Kumagai, H Tomoda, H Tanaka, H Nagashima, H Hashizume, S Omura.   

Abstract

Simple and efficient syntheses of 1233A analogs were developed and the inhibitory activity of the analogs against hydroxymethylglutaryl coenzyme A (HMG-CoA) synthase was determined. Study of the structure-activity relationships revealed that not only the geometry in beta-lactone moiety but also the length of the carbon side chain is important for inhibitory activity against HMG-CoA synthase.

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Year:  1992        PMID： 1355474     DOI： 10.7164/antibiotics.45.1139

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  2 in total

1.  The molecular pruning of a phosphoramidate peptidomimetic inhibitor of prostate-specific membrane antigen.

Authors:  Lisa Y Wu; Marc O Anderson; Yoko Toriyabe; Jack Maung; Tammy Y Campbell; Cheryl Tajon; Marat Kazak; Jamie Moser; Clifford E Berkman
Journal:  Bioorg Med Chem       Date:  2007-08-21       Impact factor: 3.641

2.  Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.

Authors:  Florence Pojer; Jean-Luc Ferrer; Stéphane B Richard; Dinesh A Nagegowda; Mee-Len Chye; Thomas J Bach; Joseph P Noel
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-24       Impact factor: 11.205
  2 in total

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