Literature DB >> 1355445

Mapping rat brain structures activated during ethanol withdrawal: role of glutamate and NMDA receptors.

P F Morgan1, N S Nadi, J Karanian, M Linnoila.   

Abstract

Brain structures activated during ethanol withdrawal have been mapped by visualizing c-fos mRNA expression. The regional distribution of c-fos mRNA in brain during ethanol withdrawal can be mimicked by acute injection of N-methyl-D-aspartic acid (NMDA) and is stereospecifically blocked by the NMDA receptor antagonist, MK-801. The findings reveal that the dentate gyrus and piriform cortex are selectively activated during ethanol withdrawal and suggest that this may be mediated by glutamate activation of NMDA receptors.

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Year:  1992        PMID： 1355445     DOI： 10.1016/0922-4106(92)90023-o

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  11 in total

1.  The Role of Presenilin-1 in the Excitotoxicity of Ethanol Withdrawal.

Authors:  Marianna E Jung; Daniel B Metzger; Hriday K Das
Journal:  J Pharmacol Exp Ther       Date:  2016-06-08       Impact factor: 4.030

Review 2.  Drugs of abuse and immediate-early genes in the forebrain.

Authors:  R E Harlan; M M Garcia
Journal:  Mol Neurobiol       Date:  1998-06       Impact factor: 5.590

3.  Limbic circuitry activation in ethanol withdrawal is regulated by a chromosome 1 locus.

Authors:  Kari J Buck; Gang Chen; Laura B Kozell
Journal:  Alcohol       Date:  2016-12-08       Impact factor: 2.405

4.  Alcohol Induces Parallel Changes in Hippocampal Histone H3 Phosphorylation and c-Fos Protein Expression in Male Rats.

Authors:  Justin A McClain; Kimberly Nixon
Journal:  Alcohol Clin Exp Res       Date:  2016-01       Impact factor: 3.455

5.  Intermittent hypoxia training blunts cerebrocortical presenilin 1 overexpression and amyloid-β accumulation in ethanol-withdrawn rats.

Authors:  Myoung-Gwi Ryou; Robert T Mallet; Daniel B Metzger; Marianna E Jung
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2017-05-10       Impact factor: 3.619

6.  Involvement of the limbic basal ganglia in ethanol withdrawal convulsivity in mice is influenced by a chromosome 4 locus.

Authors:  Gang Chen; Laura B Kozell; Robert Hitzemann; Kari J Buck
Journal:  J Neurosci       Date:  2008-09-24       Impact factor: 6.167

7.  The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice.

Authors:  Katherine R Gililland-Kaufman; Michelle A Tanchuck; Matthew M Ford; John C Crabbe; Amy S Beadles-Bohling; Christopher Snelling; Gregory P Mark; Deborah A Finn
Journal:  Brain Res       Date:  2008-09-24       Impact factor: 3.252

8.  Differential activation of limbic circuitry associated with chronic ethanol withdrawal in DBA/2J and C57BL/6J mice.

Authors:  Gang Chen; Matthew T Reilly; Laura B Kozell; Robert Hitzemann; Kari J Buck
Journal:  Alcohol       Date:  2009-09       Impact factor: 2.405

9.  Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice.

Authors:  R E Gorin-Meyer; K M Wiren; M A Tanchuck; S L Long; N Yoneyama; D A Finn
Journal:  Neuroscience       Date:  2007-04-11       Impact factor: 3.590

10.  Midazolam and the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-7-phosphonoheptanoic acid (AP-7) attenuate stress-induced expression of c-fos mRNA in the dentate gyrus.

Authors:  R Titze-de-Almeida; C L de Oliveira; H W Shida; F S Guimarães; E A Del Bel
Journal:  Cell Mol Neurobiol       Date:  1994-08       Impact factor: 5.046
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