Literature DB >> 1355437

Carvedilol, a new beta-adrenoceptor antagonist and vasodilator antihypertensive drug, inhibits superoxide release from human neutrophils.

T L Yue1, P J McKenna, R R Ruffolo, G Feuerstein.   

Abstract

Carvedilol produced a dose-dependent inhibition of superoxide (O2-) release from human neutrophils (PMNs) (IC50 = 28 microM) and scavenged O2- generated during dihydroxyfumaric acid (DHF) autooxidation (IC50 = 41 microM). Other beta-blockers, such as celiprolol, labetalol and atenolol, or the antioxidant, 'lazaroid', U74500A had no effect on O2- either released from PMNs or generated during DHF autooxidation. Propranolol, at 0.3 mM, inhibited O2- release from PMNs (73%) but failed to scavenge O2- generated from DHF. The novel free radical-scavenging effect of carvedilol may contribute to the cardioprotective activity of the compound.

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Year:  1992        PMID： 1355437     DOI： 10.1016/0014-2999(92)90130-v

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  14 in total

1.  The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling.

Authors:  Samuel Mon-Wei Yu; Pierre-Yves Jean-Charles; Dennis M Abraham; Suneet Kaur; Clarice Gareri; Lan Mao; Howard A Rockman; Sudha K Shenoy
Journal:  J Biol Chem       Date:  2018-12-11       Impact factor: 5.157

Review 2.  An overview of the pharmacodynamic properties and therapeutic potential of combined alpha- and beta-adrenoceptor antagonists.

Authors:  P A van Zwieten
Journal:  Drugs       Date:  1993-04       Impact factor: 9.546

Review 3.  Evolving therapeutic concepts and imaging in ischemic cardiomyopathy.

Authors:  A Lahiri; R Senior
Journal:  J Nucl Cardiol       Date:  1998 Nov-Dec       Impact factor: 5.952

Review 4.  Carvedilol. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders.

Authors:  C J Dunn; A P Lea; A J Wagstaff
Journal:  Drugs       Date:  1997-07       Impact factor: 9.546

Review 5.  Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.

Authors:  Xin Gen Lei; Jian-Hong Zhu; Wen-Hsing Cheng; Yongping Bao; Ye-Shih Ho; Amit R Reddi; Arne Holmgren; Elias S J Arnér
Journal:  Physiol Rev       Date:  2016-01       Impact factor: 37.312

Review 6.  Use of biomarkers for the assessment of chemotherapy-induced cardiac toxicity.

Authors:  Eric S Christenson; Theodore James; Vineet Agrawal; Ben H Park
Journal:  Clin Biochem       Date:  2014-11-07       Impact factor: 3.281

7.  Carvedilol attenuates neuroleptic-induced orofacial dyskinesia: possible antioxidant mechanisms.

Authors:  Pattipati S Naidu; Amanpreet Singh; Shrinivas K Kulkarni
Journal:  Br J Pharmacol       Date:  2002-05       Impact factor: 8.739

Review 8.  Central nervous system agents for ischemic stroke: neuroprotection mechanisms.

Authors:  Rachna S Pandya; Lijuan Mao; Hua Zhou; Shuanhu Zhou; Jiang Zeng; A John Popp; Xin Wang
Journal:  Cent Nerv Syst Agents Med Chem       Date:  2011-06-01

9.  Inhibition by gomisin C (a lignan from Schizandra chinensis) of the respiratory burst of rat neutrophils.

Authors:  J P Wang; S L Raung; M F Hsu; C C Chen
Journal:  Br J Pharmacol       Date:  1994-11       Impact factor: 8.739

Review 10.  Carvedilol: a review of its use in chronic heart failure.

Authors:  Gillian M Keating; Blair Jarvis
Journal:  Drugs       Date:  2003       Impact factor: 9.546
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