| Literature DB >> 1355405 |
L Hou1, D Shi, S M Tu, H Z Zhang, M C Hung, D Ling.
Abstract
Monoclonal antibody PAb3 to c-erbB-2/neu protein was utilized in the immunoperoxidase staining of 86 human specimens from oral mucosa. These tissue specimens represented a spectrum from 7 normal to 9 simple hyperplasia, 15 mild dysplasia, 14 moderate dysplasia, 20 severe dysplasia and 21 squamous cell carcinoma. Our study indicated that as the cells acquire a more malignant phenotype, there was a progressive increase in neu expression. It also suggested that neu may be involved in the development of oral cancers and that its evaluation in the early stages may assist in the diagnosis and management of oral cancers.Entities:
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Year: 1992 PMID： 1355405 DOI： 10.1016/0304-3835(92)90234-m
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679