Literature DB >> 13549645

The formation of myeloma protein by a mouse plasma cell tumor.

D NATHANS, J L FAHEY, M POTTER.   

Abstract

The origin of the myeloma protein found in mice bearing the plasma cell tumor X5563 has been investigated. Specific activity-time curves of the myeloma proteins isolated from the tumor and from the plasma of these animals were compared following intravenous injection of L-lysine-C(14). The results indicate that myeloma protein is synthesized in the plasma cell tumor.

Entities:  

Keywords:  MYELOMA, PLASMA CELL/experimental

Mesh：

Substances：

Year:  1958        PMID： 13549645      PMCID： PMC2136887          DOI： 10.1084/jem.108.1.121

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  11 in total

1.  Abnormal serum protein and bone destruction in transmissible mouse plasma cell neoplasm (multiple myeloma).

Authors:  M POTTER; J L FAHEY; H I PILGRIM
Journal:  Proc Soc Exp Biol Med       Date:  1957-02

2.  Chromatography of serum proteins in normal and pathologic sera: the distribution of protein-bound carbohydrate and cholesterol, siderophilin, thyroxin-binding protein, B12-binding protein, alkaline and acid phosphatases, radio-iodinated albumin and myeloma proteins.

Authors:  J L FAHEY; P F McCOY; M GOULIAN
Journal:  J Clin Invest       Date:  1958-02       Impact factor: 14.808

3.  Localization of pathological protein synthesis in multiple myelomatosis.

Authors:  J B SOONS
Journal:  Acta Physiol Pharmacol Neerl       Date:  1956-07

4.  The spectrophotometric determination of tyrosine and tryptophan in proteins.

Authors:  T W Goodwin; R A Morton
Journal:  Biochem J       Date:  1946       Impact factor: 3.857

5.  The separation of N-2:4-dinitrophenly amino-acids on paper chromatograms.

Authors:  S BLACKBURN; A G LOWTHER
Journal:  Biochem J       Date:  1951-01       Impact factor: 3.857

6.  Metabolism of C14 labeled glycine, L-histidine, L-leucine, and L-lysine.

Authors:  H BORSOOK; C L DEASY; A J HAAGENSMIT; G KEIGHLEY; P H LOWY
Journal:  J Biol Chem       Date:  1950-12       Impact factor: 5.157

7.  Multiple myeloma. III. Effect of urethane therapy on plasma cell growth, abnormal serum protein components and Bence Jones proteinuria.

Authors:  R W RUNDLES; M L DILLON; E S DILLON
Journal:  J Clin Invest       Date:  1950-09       Impact factor: 14.808

8.  Kinetics of amino acid incorporation into serum proteins.

Authors:  H GREEN; H S ANKER
Journal:  J Gen Physiol       Date:  1955-01-20       Impact factor: 4.086

9.  Protein synthesis in the perfused rat liver.

Authors:  D JENSEN; H TARVER
Journal:  J Gen Physiol       Date:  1956-03-20       Impact factor: 4.086

10.  The dominant role of the liver in plasma protein synthesis; a direct study of the isolated perfused rat liver with the aid of lysine-epsilon-C14.

Authors:  L L MILLER; C G BLY; M L WATSON; W F BALE
Journal:  J Exp Med       Date:  1951-11       Impact factor: 14.307
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  18 in total

1.  A study on globulin formation by plasma-cell neoplasm (5563) transplantable in mice.

Authors:  B A ASKONAS
Journal:  Biochem J       Date:  1961-04       Impact factor: 3.857

2.  Formation of Bence-Jones protein and myeloma protein in vitro by the plasma-cell tumour MPC-2.

Authors:  B A ASKONAS; J L FAHEY
Journal:  Biochem J       Date:  1961-08       Impact factor: 3.857

3.  Serum free light chains in myeloma patients with an intact M protein by immunofixation: potential roles for response assessment and prognosis during induction therapy with novel agents.

Authors:  Sherry Mori; Brooke S Crawford; Julianna Vf Roddy; Gary Phillips; Pat Elder; Craig C Hofmeister; Yvonne Efebera; Don M Benson
Journal:  Hematol Oncol       Date:  2011-10-26       Impact factor: 5.271

4.  THE METABOLISM OF NORMAL PLASMA PROTEINS AND GAMMA-MYELOMA PROTEIN IN MICE BEARING PLASMA-CELL TUMORS.

Authors:  J H Humphrey; J L Fahey
Journal:  J Clin Invest       Date:  1961-09       Impact factor: 14.808

Review 5.  Here, There, and Anywhere? Arguments for and against the Physical Plasma Cell Survival Niche.

Authors:  Joel R Wilmore; David Allman
Journal:  J Immunol       Date:  2017-08-01       Impact factor: 5.422

6.  Our NIH years: a confluence of beginnings.

Authors:  Leonore A Herzenberg; Leonard A Herzenberg
Journal:  J Biol Chem       Date:  2012-10-12       Impact factor: 5.157

Review 7.  Immunocytoma o' mice an' men.

Authors:  J R Hobbs
Journal:  Br Med J       Date:  1971-04-10

Review 8.  Myeloma proteins.

Authors:  M Potter
Journal:  Experientia       Date:  1986-09-15

Review 9.  Protein analyses in myelomatosis.

Authors:  P M Carter; L Slater; J Lee; D Perry; J R Hobbs
Journal:  J Clin Pathol Suppl (Assoc Clin Pathol)       Date:  1975

10.  Immunoglobulin synthesis and total body tumor cell number in IgG multiple myeloma.

Authors:  S E Salmon; B A Smith
Journal:  J Clin Invest       Date:  1970-06       Impact factor: 14.808
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