| Literature DB >> 1354740 |
D A Lewis1, W N Field, K Hayes, H O Alpar.
Abstract
Free hydrocortisone, hydrocortisone incorporated into microspheres and empty microspheres have been administered orally to rats with carrageenan-induced hindpaw inflammation. Hydrocortisone administered in particles was effective at a lower dose than free steroid in reducing inflammation. Inflammatory exudates were able to release steroid from the microspheres by proteolytic degradation.Entities:
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Year: 1992 PMID： 1354740 DOI： 10.1111/j.2042-7158.1992.tb03600.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765