Literature DB >> 1354728

Time course of PAF formation by gastrointestinal tissue in rats after castor oil challenge.

A Pinto1, G Autore, N Mascolo, R Sorrentino, A Biondi, A A Izzo, F Capasso.   

Abstract

When castor oil was administered by gavage to rats, the duodenum and jejunum, but not the stomach, produced large amounts of platelet activating factor 3-7 h after oil challenge with a peak at 3 h. Intraluminal release of acid phosphatase was also markedly increased in the duodenum and jejunum of castor oil-treated rats, especially 3-5 h after oil challenge. No increase was observed in the stomach. There was a correlation between elevated release of acid phosphatase and intestinal hyperaemia.

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Year:  1992        PMID: 1354728     DOI: 10.1111/j.2042-7158.1992.tb03586.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN: 0022-3573            Impact factor:   3.765


  6 in total

1.  Prostaglandin E2 and reactive oxygen metabolite damage in the cecum in a pony model of acute colitis.

Authors:  Rebecca S McConnico; Robert A Argenzio; Malcolm C Roberts
Journal:  Can J Vet Res       Date:  2002-01       Impact factor: 1.310

2.  Inhibitors of nitric oxide synthetase prevent castor-oil-induced diarrhoea in the rat.

Authors:  N Mascolo; A A Izzo; F Barbato; F Capasso
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

3.  Dissociation of castor oil-induced diarrhoea and intestinal mucosal injury in rat: effect of NG-nitro-L-arginine methyl ester.

Authors:  F Capasso; N Mascolo; A A Izzo; T S Gaginella
Journal:  Br J Pharmacol       Date:  1994-12       Impact factor: 8.739

4.  Relationship between nitric oxide and platelet-activating factor in castor-oil induced mucosal injury in the rat duodenum.

Authors:  N Mascolo; A A Izzo; T S Gaginella; F Capasso
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-05       Impact factor: 3.000

5.  Role of the Rosa canina L. leaf extract as an antidiarrheal drug in rodents.

Authors:  Rajesh J Mandade; Avijit Choudhury; Amol Harsulkar; Ravikiran Wakade
Journal:  Indian J Pharmacol       Date:  2011-05       Impact factor: 1.200

6.  Evaluation of Antidiarrheal Activity of Methanolic Extract of Maranta arundinacea Linn. Leaves.

Authors:  Md Khalilur Rahman; Md Ashraf Uddin Chowdhury; Mohammed Taufiqual Islam; Md Anisuzzaman Chowdhury; Muhammad Erfan Uddin; Chandra Datta Sumi
Journal:  Adv Pharmacol Sci       Date:  2015-08-06
  6 in total

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