| Literature DB >> 1354551 |
Y Minamoto1, T Itano, M Tokuda, H Matsui, N A Janjua, K Hosokawa, Y Okada, T H Murakami, T Negi, O Hatase.
Abstract
Extracellular concentrations of gamma-aminobutyric acid (GABA), glutamate (Glu) and aspartate (Asp) were determined by microdialysis in rat hippocampus during various amygdaloid kindled stages. The values of GABA and Glu were increased 3-4 times in C2-C3 stages in comparison with the values in control animals. After reaching the C5 stages, these values were increased 3-7 times. However, the concentration of Asp decreased depending on the kindling stage, reaching the lowest value of 33% in comparison with the normal value. The observed changes may be related to kindling induced seizures.Entities:
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Year: 1992 PMID： 1354551 DOI： 10.1016/0006-8993(92)90786-9
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252