Literature DB >> 13536277

Effects of rate of stimulation and of fatigue on the response to neuromuscular blocking agents.

L WISLICKI.   

Abstract

The response to neuromuscular blocking agents, as exemplified by suxamethonium and tubocurarine, may differ between symmetrical muscles. Increased rates of stimulation and fatigue both increase sensitivity to blocking agents. During recovery from suxamethonium block muscles may show a transitory failure to react to each stimulus with a contraction. Fatigue caused by prolonged indirect stimulation is prevented equally well by suxamethonium and tubocurarine in doses producing a complete block. The mechanism and significance of these findings are discussed.

Entities:  

Keywords:  FATIGUE; MYONEURAL JUNCTION/effect of drugs on

Mesh：

Substances：

Year:  1958        PMID： 13536277      PMCID： PMC1481727          DOI： 10.1111/j.1476-5381.1958.tb00208.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  9 in total

1.  The relation between force and integrated electrical activity in fatigued muscle.

Authors:  R G EDWARDS; O C LIPPOLD
Journal:  J Physiol       Date:  1956-06-28       Impact factor: 5.182

2.  Voluntary strength and fatigue.

Authors:  P A MERTON
Journal:  J Physiol       Date:  1954-03-29       Impact factor: 5.182

3.  Suxamethonium (succinylcholine) chloride and muscle pains.

Authors:  H C CHURCHILL-DAVIDSON
Journal:  Br Med J       Date:  1954-01-09

4.  An electrical investigation of effects of repetitive stimulation on mammalian neuromuscular junction.

Authors:  A W LILEY; K A NORTH
Journal:  J Neurophysiol       Date:  1953-09       Impact factor: 2.714

5.  The principles of neuromusclular block.

Authors:  W D PATON
Journal:  Anaesthesia       Date:  1953-07       Impact factor: 6.955

6.  Effects of frequency of stimulation on the paralyzing dose of neuromuscular blocking agents.

Authors:  J B PRESTON; E F VAN MAANEN
Journal:  J Pharmacol Exp Ther       Date:  1953-02       Impact factor: 4.030

7.  The isometric responses of mammalian muscles.

Authors:  S Cooper
Journal:  J Physiol       Date:  1930-06-27       Impact factor: 5.182

8.  Early respiratory depression by curare and curarepotassium antagonism.

Authors:  T H LI; B R JACOBS; D M AVIADO; C F SCHMIDT
Journal:  J Pharmacol Exp Ther       Date:  1952-02       Impact factor: 4.030

9.  The dynamics of curarization.

Authors:  A C GUYTON; R C REEDER
Journal:  J Pharmacol Exp Ther       Date:  1949-11       Impact factor: 4.030
  9 in total
  4 in total

1.  Stimulus frequency and neuromuscular block.

Authors:  J G BLACKMAN
Journal:  Br J Pharmacol Chemother       Date:  1963-02

2.  Characteristics of nondepolarizing neuromuscular block: (I) post-junctional block by alpha-bungarotoxin.

Authors:  C Lee; D Chen; R L Katz
Journal:  Can Anaesth Soc J       Date:  1977-03

3.  Clinical assessment of neuromuscular transmission.

Authors:  J P Payne; R Hughes
Journal:  Br J Clin Pharmacol       Date:  1981-06       Impact factor: 4.335

4.  Studies on the blocking action of 2-(4-phenyl piperidino) cyclohexanol (AH5183).

Authors:  I G Marshall
Journal:  Br J Pharmacol       Date:  1970-05       Impact factor: 8.739
  4 in total

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