Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A new Conus peptide ligand for mammalian presynaptic Ca2+ channels.

Literature DB >> 1352986

A new Conus peptide ligand for mammalian presynaptic Ca2+ channels.

D R Hillyard¹, V D Monje, I M Mintz, B P Bean, L Nadasdi, J Ramachandran, G Miljanich, A Azimi-Zoonooz, J M McIntosh, L J Cruz.

Abstract

Voltage-sensitive Ca2+ channels that control neurotransmitter release are blocked by omega-conotoxin (omega-CgTx) GVIA from the marine snail Conus geographus, the most widely used inhibitor of neurotransmitter release. However, many mammalian synapses are omega-CgTx-GVIA insensitive. We describe a new Conus peptide, omega-CgTx-MVIIC, that is an effective inhibitor of omega-CgTx-GVIA-resistant synaptic transmission. Ca2+ channel targets that are inhibited by omega-CgTx-MVIIC but not by omega-CgTx-GVIA include those mediating depolarization-induced 45Ca2+ uptake in rat synaptosome preparations, "P" currents in cerebellar Purkinje cells, and a subset of omega-CgTx-GVIA-resistant currents in CA1 hippocampal pyramidal cells. The characterization of omega-CgTx-MVIIC by a combination of molecular genetics and chemical synthesis defines a general approach for obtaining ligands with novel receptor subtype specificity from Conus.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1992 PMID： 1352986 DOI： 10.1016/0896-6273(92)90221-x

Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173

Keyword Cloud
Cited

121 in total

1. delta opioid receptor modulation of several voltage-dependent Ca(2+) currents in rat sensory neurons.

Authors: C G Acosta; H S López
Journal: J Neurosci Date: 1999-10-01 Impact factor: 6.167

2. Properties of Q-type calcium channels in neostriatal and cortical neurons are correlated with beta subunit expression.

Authors: P G Mermelstein; R C Foehring; T Tkatch; W J Song; G Baranauskas; D J Surmeier
Journal: J Neurosci Date: 1999-09-01 Impact factor: 6.167

3. Calcium channels involved in the inhibition of acetylcholine release by presynaptic muscarinic receptors in rat striatum.

Authors: V Dolezal; S Tucek
Journal: Br J Pharmacol Date: 1999-08 Impact factor: 8.739

A new Conus peptide ligand for mammalian presynaptic Ca2+ channels.

1. delta opioid receptor modulation of several voltage-dependent Ca(2+) currents in rat sensory neurons.

2. Properties of Q-type calcium channels in neostriatal and cortical neurons are correlated with beta subunit expression.

3. Calcium channels involved in the inhibition of acetylcholine release by presynaptic muscarinic receptors in rat striatum.

4. Proportions of Ca2+ channel subtypes in chick or rat P2 fraction and NG108-15 cells using various Ca2+ blockers.

5. N-type calcium channels and their regulation by GABAB receptors in axons of neonatal rat optic nerve.

6. Ca(2+) influx inhibits dynamin and arrests synaptic vesicle endocytosis at the active zone.

7. An R-type Ca(2+) current in neurohypophysial terminals preferentially regulates oxytocin secretion.

8. R-Type Ca2+ channels are coupled to the rapid component of secretion in mouse adrenal slice chromaffin cells.

9. Kurtoxin, a gating modifier of neuronal high- and low-threshold ca channels.

10. Calcium influx is required for endocytotic membrane retrieval.