Literature DB >> 1352936

Study of the mechanism of prostacyclin (PgI2) action on myocardial contractility.

M Pavlović1, D Petković, M Cvetković, K Zdjelar, V Starcević, O Bosnić.   

Abstract

The experiments done on the isolated right ventricle of rat heart suspended in the bath for isolated organs with oxygenated Tyrode's solution showed the PgI2 (2.3 x 10-6 mmol) produced its positive inotropic effect indirectly by promoting both beta-adrenoreceptors and calcium entry through slow calcium channels because this effect could be blocked by propranolol (2.3 x 10-2 mmol - beta-adrenoreceptor blocker) or verapamil (4.3 x 10-3 mmol - slow calcium channel blocker).

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Year:  1992        PMID: 1352936     DOI: 10.1007/978-3-0348-7262-1_23

Source DB:  PubMed          Journal:  Agents Actions Suppl        ISSN: 0379-0363


  3 in total

1.  Prostanoids but not oral therapies improve right ventricular function in pulmonary arterial hypertension.

Authors:  Evan L Brittain; Meredith E Pugh; Lisa A Wheeler; Ivan M Robbins; James E Loyd; John H Newman; Eric D Austin; Anna R Hemnes
Journal:  JACC Heart Fail       Date:  2013-08       Impact factor: 12.035

2.  Sildenafil monotherapy in portopulmonary hypertension can facilitate liver transplantation.

Authors:  Anna R Hemnes; Ivan M Robbins
Journal:  Liver Transpl       Date:  2009-01       Impact factor: 5.799

3.  The prostaglandins epoprostenol and iloprost increase left ventricular contractility in vivo.

Authors:  Hille Kisch-Wedel; Gregor Kemming; Franz Meisner; Michael Flondor; Wolfgang M Kuebler; Sebastian Bruhn; Carolina Koehler; Bernhard Zwissler
Journal:  Intensive Care Med       Date:  2003-08-08       Impact factor: 17.440

  3 in total

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