Literature DB >> 1352721

Release of vasoactive intestinal polypeptide from the rat gastric fundus.

M D'Amato1, D Currò, P Montuschi, G Ciabattoni, E Ragazzoni, R A Lefebvre.   

Abstract

1. Auxotonic responses and release of vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) induced by electrical field stimulation (EFS) were studied in longitudinal muscle strips from the gastric fundus of reserpinized rats suspended between parallel platinum electrodes in Krebs solution containing atropine (1 microM), 5-hydroxytryptamine (3 microM) and bovine serum albumin (50 mg l-1). 2. EFS (supramaximal voltage, 1 ms, 0.25-32.0 Hz, trains of 2 min) induced frequency-dependent relaxations. 3. EFS at frequencies greater than or equal to 8 Hz also produced significant increases in VIP-LI release. 4. VIP-LI release induced by EFS at 16 Hz no longer occurred in the presence of tetrodotoxin (1 microM) or a Ca(2+)-free medium. 5. Detection of VIP-LI upon activation of inhibitory non-adrenergic, non-cholinergic neurones indicates that VIP meets the 'detectable release' criterion for an inhibitory neurotransmitter in the rat gastric fundus.

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Year:  1992        PMID： 1352721      PMCID： PMC1908460          DOI： 10.1111/j.1476-5381.1992.tb09040.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  13 in total

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Journal:  J Pharmacol Exp Ther       Date:  1991-02       Impact factor: 4.030

Review 5.  Criteria for the identification of central neurotransmitters, and their application to studies with some nerve tissue preparations in vitro.

Authors:  F Orrego
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7.  A sensitive method for the assay of 5-hydroxytryptamine.

Authors:  J R VANE
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8.  Is peptide histidine isoleucine an inhibitory nonadrenergic noncholinergic neurotransmitter in the rat gastric fundus?

Authors:  M D'Amato; D Currò; G Ciabattoni; R A Lefebvre
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9.  Study on the possible neurotransmitter of the non-adrenergic non-cholinergic innervation of the rat gastric fundus.

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Journal:  Arch Int Pharmacodyn Ther       Date:  1986-04

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Authors:  C G Li; M J Rand
Journal:  Eur J Pharmacol       Date:  1990-12-04       Impact factor: 4.432
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  16 in total

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2.  Development of cholinergic and inhibitory non-adrenergic non-cholinergic responses in the rat gastric funds.

Authors:  G J Smits; R A Lefebvre
Journal:  Br J Pharmacol       Date:  1996-08       Impact factor: 8.739

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Authors:  A J Barbier; R A Lefebvre
Journal:  Br J Pharmacol       Date:  1994-04       Impact factor: 8.739

5.  Effects of vasoactive intestinal polypeptide on antigen-induced bronchoconstriction and thromboxane release in guinea-pig lung.

Authors:  G Ciabattoni; P Montuschi; D Currò; G Togna; P Preziosi
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6.  Nitric oxide synthase activity and non-adrenergic non-cholinergic relaxation in the rat gastric fundus.

Authors:  D Currò; A R Volpe; P Preziosi
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

7.  Modulation of non-adrenergic non-cholinergic inhibitory neurotransmission in rat gastric fundus by the alpha 2-adrenoceptor agonist, UK-14,304.

Authors:  R A Lefebvre; G J Smits
Journal:  Br J Pharmacol       Date:  1992-09       Impact factor: 8.739

8.  Distribution of NADPH diaphorase-positive neurons in the enteric nervous system of the rabbit intestine.

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9.  Nitric oxide, an enteric nonadrenergic-noncholinergic relaxant transmitter: evidence using phosphodiesterase V and nitric oxide synthase inhibition.

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Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739

10.  Heme deficiency of soluble guanylate cyclase induces gastroparesis.

Authors:  S M R Cosyns; I Dhaese; R Thoonen; E S Buys; A Vral; P Brouckaert; R A Lefebvre
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