Literature DB >> 135268

Parachlorophenylalanine potentiates facilitatory effects of mescaline on shuttlebox escape/avoidance in rats.

D M Stoff, R J Wyatt, J C Gillin.   

Abstract

Acute parachlorophenylalanine (pCPA) pretreatment (150 mg/kg, i.p., 24 h beforehand) potentiated facilitatory effects of mescaline (39.6 mg/kg i.p.) on shuttlebox escape/avoidance in hooded rats, tested in two different situations: 1. during aquisition of avoidance behavior (Experiment 1); and 2. in stable pretrained poor avoiders (Experiment 2). pCPA alone did not influence avoidance behavior in either situation. Mescaline, with pCPA pretreatment, may be associated with long-term behavioral effects; all rats treated with this combination were later found to be poor avoiders, unable to achieve a stable baseline of good avoidance. pCPA significantly depleted brain norepinephrine and dopamine, as well as serotonin, measured after testing in the second situation.

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Year:  1976        PMID： 135268     DOI： 10.1007/bf00427615

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  29 in total

1.  A BIOCHEMICAL AND PHARMACOLOGICAL SUGGESTION ABOUT CERTAIN MENTAL DISORDERS.

Authors:  D W Woolley; E Shaw
Journal:  Proc Natl Acad Sci U S A       Date:  1954-04       Impact factor: 11.205

2.  Ontogeny of serotonergic inhibition of behavioral arousal in the rat.

Authors:  P D Mabry; B A Campbell
Journal:  J Comp Physiol Psychol       Date:  1974-02

3.  Serotonergic inhibition of catecholamine-induced behavioral arousal.

Authors:  P D Mabry; B A Campbell
Journal:  Brain Res       Date:  1973-01-30       Impact factor: 3.252

4.  Comparative effects of p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid.

Authors:  F P Miller; R H Cox; W R Snodgrass; R P Maickel
Journal:  Biochem Pharmacol       Date:  1970-02       Impact factor: 5.858

5.  A comparison of psychotomimetic drug effects on rat brain norepinephrine metabolism.

Authors:  J M Stolk; J D Barchas; M Goldstein; W Boggan; D X Freedman
Journal:  J Pharmacol Exp Ther       Date:  1974-04       Impact factor: 4.030

6.  Mescaline: no tolerance to excitatory effects.

Authors:  W H Bridger; I J Mandel; D M Stoff
Journal:  Biol Psychiatry       Date:  1973-10       Impact factor: 13.382

7.  Acute and chronic effects of LSD and 3,4-dimethoxyphenylethylamine on shuttlebox escape-avoidance in rats.

Authors:  D M Stoff; I J Mandel; D A Gorelick; W H Bridger
Journal:  Psychopharmacologia       Date:  1974-05-15

8.  Brain levels of serotonin (5-HT) and norepinephrine (NE) during mescaline-induced behavior in mice.

Authors:  N S Shah
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1973-01

9.  Behavioural and brain neurohormonal changes produced by acute heat stress in rats: influence of psychopharmacological agents.

Authors:  M K Menon; P C Dandiya
Journal:  Eur J Pharmacol       Date:  1969-12       Impact factor: 4.432

10.  The effects of p-chlorophenylalanine, a serotonin depletor, on avoidance acquisition, pain sensitivity and related behavior in the rat.

Authors:  S S Tenen
Journal:  Psychopharmacologia       Date:  1967
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  2 in total

1.  Separation of the associative and non-associative effects of brain serotonin released by p-chloroamphetamine: dissociable serotoninergic involvement in avoidance learning, pain and motor function.

Authors:  S O Ogren; C Johansson
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

2.  Mescaline: excitatory effects on acoustic startle are blocked by serotonin2 antagonists.

Authors:  M Davis
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530
  2 in total

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