Literature DB >> 1352613

Dopamine transporter mRNA: dense expression in ventral midbrain neurons.

S Shimada1, S Kitayama, D Walther, G Uhl.   

Abstract

Oligonucleotides and a full-length cDNA encoding a functional dopamine transporter (DAT1) hybridize to a 3.7 kb mRNA that is concentrated in mRNA prepared from midbrain and absent in specimens from cerebellum or cerebral cortex. In situ hybridization reveals substantial hybridization densities overlying neurons of the substantia nigra, pars compacta, and the parabrachialis pigmentosus region of the ventral tegmental area (VTA). Neurons in the linear and paranigral VTA regions display lower levels of expression. Preliminary studies in arcuate neurons suggest modest hybridization. Different dopaminergic cell groups display different levels of DAT1 dopamine transporter expression.

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Year:  1992        PMID： 1352613     DOI： 10.1016/0169-328x(92)90220-6

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  29 in total

1.  Dopamine release and uptake dynamics within nonhuman primate striatum in vitro.

Authors:  S J Cragg; C J Hille; S A Greenfield
Journal:  J Neurosci       Date:  2000-11-01       Impact factor: 6.167

2.  Differential autoreceptor control of somatodendritic and axon terminal dopamine release in substantia nigra, ventral tegmental area, and striatum.

Authors:  S J Cragg; S A Greenfield
Journal:  J Neurosci       Date:  1997-08-01       Impact factor: 6.167

3.  The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens.

Authors:  M J Nirenberg; J Chan; A Pohorille; R A Vaughan; G R Uhl; M J Kuhar; V M Pickel
Journal:  J Neurosci       Date:  1997-09-15       Impact factor: 6.167

4.  VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity.

Authors:  N Takahashi; L L Miner; I Sora; H Ujike; R S Revay; V Kostic; V Jackson-Lewis; S Przedborski; G R Uhl
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

5.  Dopamine Regulates Aversive Contextual Learning and Associated In Vivo Synaptic Plasticity in the Hippocampus.

Authors:  John I Broussard; Kechun Yang; Amber T Levine; Theodoros Tsetsenis; Daniel Jenson; Fei Cao; Isabella Garcia; Benjamin R Arenkiel; Fu-Ming Zhou; Mariella De Biasi; John A Dani
Journal:  Cell Rep       Date:  2016-02-18       Impact factor: 9.423

6.  Amphetamine potency varies with dopamine uptake rate across striatal subregions.

Authors:  Cody A Siciliano; Erin S Calipari; Sara R Jones
Journal:  J Neurochem       Date:  2014-07-30       Impact factor: 5.372

7.  MP1104, a mixed kappa-delta opioid receptor agonist has anti-cocaine properties with reduced side-effects in rats.

Authors:  Diana V Atigari; Rajendra Uprety; Gavril W Pasternak; Susruta Majumdar; Bronwyn M Kivell
Journal:  Neuropharmacology       Date:  2019-02-13       Impact factor: 5.250

8.  Regional dopamine transporter gene expression in the substantia nigra from control and Parkinson's disease brains.

Authors:  T J Counihan; J B Penney
Journal:  J Neurol Neurosurg Psychiatry       Date:  1998-08       Impact factor: 10.154

9.  Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons.

Authors:  Dong-Youn Hwang; Sunghoi Hong; Joo-Won Jeong; Sangdun Choi; Hansoo Kim; Jangwoo Kim; Kwang-Soo Kim
Journal:  J Neurochem       Date:  2009-09-24       Impact factor: 5.372

10.  Vulnerability of mesostriatal dopaminergic neurons in Parkinson's disease.

Authors:  Tomás González-Hernández; Ignacio Cruz-Muros; Domingo Afonso-Oramas; Josmar Salas-Hernandez; Javier Castro-Hernandez
Journal:  Front Neuroanat       Date:  2010-10-20       Impact factor: 3.856
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