Literature DB >> 1352354

Confirmation of an association between RFLPs at the transforming growth factor-alpha locus and non-syndromic cleft lip and palate.

S E Holder1, G M Vintiner, B Farren, S Malcolm, R M Winter.   

Abstract

Three RFLPs at the TGFA locus were studied in 60 unrelated British Caucasian subjects with non-syndromic cleft lip/palate and 60 controls. A highly significant association between the TaqI RFLP and the occurrence of clefting was found (chi 2 = 15.04, p = less than 0.001). No significant association was found with the two other RFLPs studied (BamHI and RsaI). Haplotypes derived from the three RFLPs at the TGFA locus also showed an over-representation of the C2A2B2 haplotype in cases compared to controls. Analyses of genotypes according to type of cleft and the presence or absence of a family history of clefting were also carried out. These results provide further support for the role of TGFA as a gene of major effect in the development of orofacial clefts in humans.

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Year:  1992        PMID： 1352354      PMCID： PMC1015988          DOI： 10.1136/jmg.29.6.390

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  10 in total

1.  Further evidence for an association between genetic variation in transforming growth factor alpha and cleft lip and palate.

Authors:  G Chenevix-Trench; K Jones; A Green; N Martin
Journal:  Am J Hum Genet       Date:  1991-05       Impact factor: 11.025

2.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

3.  Association of genetic variation of the transforming growth factor-alpha gene with cleft lip and palate.

Authors:  H H Ardinger; K H Buetow; G I Bell; J Bardach; D R VanDemark; J C Murray
Journal:  Am J Hum Genet       Date:  1989-09       Impact factor: 11.025

4.  Mapping the cleft-lip genes: the first fix?

Authors:  F C Fraser
Journal:  Am J Hum Genet       Date:  1989-09       Impact factor: 11.025

5.  Segregation analysis of cleft lip with or without cleft palate: a comparison of Danish and Japanese data.

Authors:  C S Chung; D Bixler; T Watanabe; H Koguchi; P Fogh-Andersen
Journal:  Am J Hum Genet       Date:  1986-11       Impact factor: 11.025

6.  Genetics of common disorders.

Authors:  C O Carter
Journal:  Br Med Bull       Date:  1969-01       Impact factor: 4.291

7.  A Taq I polymorphism for the human transforming growth factor alpha gene (TGFA).

Authors:  N K Hayward; D J Nancarrow; G I Bell
Journal:  Nucleic Acids Res       Date:  1987-07-10       Impact factor: 16.971

8.  RFLPs for epidermal growth factor (EGF), a single copy sequence at 4q25-4q27.

Authors:  J C Murray; C R DeHaven; G I Bell
Journal:  Nucleic Acids Res       Date:  1986-06-25       Impact factor: 16.971

9.  No evidence of linkage between the transforming growth factor-alpha gene in families with apparently autosomal dominant inheritance of cleft lip and palate.

Authors:  G M Vintiner; S E Holder; R M Winter; S Malcolm
Journal:  J Med Genet       Date:  1992-06       Impact factor: 6.318

10.  Orofacial clefts in Czechoslovakia. Incidence, genetics and prevention of cleft lip and palate over a 19-year period.

Authors:  M Tolarová
Journal:  Scand J Plast Reconstr Surg Hand Surg       Date:  1987
  10 in total
  26 in total

1.  Genetics of cleft lip and palate : a review.

Authors:  Zainul Ahmad Rajion; Zilfalil Alwi
Journal:  Malays J Med Sci       Date:  2007-01

2.  GFA Taq I polymorphism and cleft lip with or without cleft palate (CL/P) risk.

Authors:  Lijia Dong; Lian Ma
Journal:  Int J Clin Exp Med       Date:  2015-03-15

Review 3.  Environmental mechanisms of orofacial clefts.

Authors:  Michael A Garland; Kurt Reynolds; Chengji J Zhou
Journal:  Birth Defects Res       Date:  2020-10-30       Impact factor: 2.344

4.  Evidence for an association between RFLPs at the transforming growth factor alpha (locus) and nonsyndromic cleft lip/palate in a South American population.

Authors:  L Jara; R Blanco; I Chiffelle; H Palomino; H Carreño
Journal:  Am J Hum Genet       Date:  1995-01       Impact factor: 11.025

Review 5.  A gene map of congenital malformations.

Authors:  A O Wilkie; J S Amberger; V A McKusick
Journal:  J Med Genet       Date:  1994-07       Impact factor: 6.318

6.  Association of transforming growth-factor alpha gene polymorphisms with nonsyndromic cleft palate only (CPO).

Authors:  R Shiang; A C Lidral; H H Ardinger; K H Buetow; P A Romitti; R G Munger; J C Murray
Journal:  Am J Hum Genet       Date:  1993-10       Impact factor: 11.025

7.  Orofacial clefts, parental cigarette smoking, and transforming growth factor-alpha gene variants.

Authors:  G M Shaw; C R Wasserman; E J Lammer; C D O'Malley; J C Murray; A M Basart; M M Tolarova
Journal:  Am J Hum Genet       Date:  1996-03       Impact factor: 11.025

8.  No evidence of linkage between the transforming growth factor-alpha gene in families with apparently autosomal dominant inheritance of cleft lip and palate.

Authors:  G M Vintiner; S E Holder; R M Winter; S Malcolm
Journal:  J Med Genet       Date:  1992-06       Impact factor: 6.318

9.  Evidence, from family studies, for linkage disequilibrium between TGFA and a gene for nonsyndromic cleft lip with or without cleft palate.

Authors:  H Feng; R Sassani; S P Bartlett; A Lee; J T Hecht; S Malcolm; R M Winter; G M Vintiner; K H Buetow; D L Gasser
Journal:  Am J Hum Genet       Date:  1994-11       Impact factor: 11.025

10.  Current concepts in genetics of nonsyndromic clefts.

Authors:  Jyotsna Murthy; Lvks Bhaskar
Journal:  Indian J Plast Surg       Date:  2009 Jan-Jun
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