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Literature DB >> 13523144

A comparison of the pituitary inhibitory effects of prednisone, prednisolone, and hydrocortisone.

Abstract

Prednisone, prednisolone and hydrocortisone, administered in doses of 1 mg. daily for thirty days, depressed the growth rate of rats. Prednisolone and hydrocortisone caused atrophy of the adrenal glands and increased the relative weights of the thyroid glands and testes. The apparently similar effects produced by prednisone were not significant. The seminal vesicles were not affected significantly by prolonged administration of prednisone, prednisolone or hydrocortisone. Pretreatment of rats with these steroids prevented the adrenal ascorbic acid depletion normally caused by laparotomy under ether anaesthesia. Prednisolone was slightly more potent and prednisone was considerably less potent than hydrocortisone in producing these effects.

Entities: Chemical Disease Species

Keywords: HYDROCORTISONE/effects; PITUITARY GLAND, ANTERIOR/effect of drugs on; PREDNISOLONE/effects; PREDNISONE/effects

Mesh：

Substances：

Year: 1958 PMID： 13523144 PMCID： PMC1481695 DOI： 10.1111/j.1476-5381.1958.tb00199.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

7 in total

1. Adrenocorticotrophic hormone in the blood of adrenalectomized rats.

Authors: G S COX; J R HODGES
Journal: Nature Date: 1958-02-08 Impact factor: 49.962

2. The comparative effects of metacortandracin, 9-alpha-fluorohydrocortisone and hydrocortisone upon ACTH secretion in man.

Authors: H S KUPPERMAN; M H BLATT; M VESELL; J GAGLIANI; H WEISBADER; L VOSBURGH
Journal: J Clin Endocrinol Metab Date: 1955-08 Impact factor: 5.958

6 in total

5. Influence of various corticoids on the augmentation of "Gomori-positive" granules in the median eminence of the rat following adrenalectomy.

Authors: H Brinkmann; R Bock
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000

6. Suppression of the hypothalamic-pituitary-adrenal axis after subcutaneous cortisone acetate administration in rats.

Authors: R B Mims
Journal: J Natl Med Assoc Date: 1977-12 Impact factor: 1.798

6 in total

A comparison of the pituitary inhibitory effects of prednisone, prednisolone, and hydrocortisone.

1. Adrenocorticotrophic hormone in the blood of adrenalectomized rats.

2. The comparative effects of metacortandracin, 9-alpha-fluorohydrocortisone and hydrocortisone upon ACTH secretion in man.

3. Metabolic effects of metacortandralone and metacortandracin.

4. The effect of desoxycorticosterone acetate on the release of adrenocorticotrophin by the pituitary gland.

5. ATROPHY OF THE ADRENAL CORTEX OF THE RAT PRODUCED BY THE ADMINISTRATION OF LARGE AMOUNTS OF CORTIN.

6. Production of reversible hyperadrenocortinism in rats by prolonged administration of cortisone.

7. [Experimental study of prednisone (metacortandracin or metacortin) in the normal and adrenalectomized rat].

1. The effect of injected corticosterone on the release of adrenocorticotrophic hormone in rats exposed to acute stress.

2. Corticotrophin release in the cortisol-treated rat.

3. The assay of corticotrophin in hypophysectomized and in hydrocortisone-treated rats.

4. [The effect of prednisone on the 17-hydroxycorticosteroids in the plasma after ACTH- and pyrexal administration].

5. Influence of various corticoids on the augmentation of "Gomori-positive" granules in the median eminence of the rat following adrenalectomy.

6. Suppression of the hypothalamic-pituitary-adrenal axis after subcutaneous cortisone acetate administration in rats.