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Literature DB >> 13523136

The relationship between 5-hydroxytryptamine and adenosine triphosphate in blood platelets.

Abstract

In normal platelets a proportionality was found between the amount of adenosine triphosphate (ATP) and amount of 5-hydroxytryptamine (5-HT) in platelets both before and after incubating them in plasma to which 5-HT had been added. In patients receiving reserpine and in others with myeloid leukaemia, the amount of 5-HT in the platelets and the uptake of 5-HT by them were depressed, while the amount of ATP was normal. The possibility that ATP is involved in the accumulation of 5-HT by platelets is discussed.

Entities: Chemical Disease Species

Keywords: ADENYLPYROPHOSPHATE/in blood; BLOOD PLATELETS/metabolism; SEROTONIN/in blood

Mesh：

Substances：

Year: 1958 PMID： 13523136 PMCID： PMC1481702 DOI： 10.1111/j.1476-5381.1958.tb00191.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

4 in total

22 in total

6. [Research on an ionexchange model for knowledge on the physiology of biogenic amines. Exchange equilibrium between sodium and amines on an ion-exchanger with R-PO(OH)2 as the active centers].

Authors: K KUETTNER; G HUBER; R JAQUES
Journal: Experientia Date: 1962-03-15

The relationship between 5-hydroxytryptamine and adenosine triphosphate in blood platelets.

1. 5-Hydroxytryptamine in normal human platelets.

2. Observations on the distribution of catechol amines and adenosinetriphosphate in the bovine adrenal medulla.

3. Reserpine and human platelet 5-hydroxytryptamine.

4. Determination of ATP and related compounds: firefly luminescence and other methods.

1. The distribution of adenosine triphosphate in subcellular fractions of brain tissue.

2. Serotonin inhibition of liver mitochondria swelling in vitro.

3. Studies on the uptake of 5-hydroxytryptamine by blood platelets.

4. The role of chelation and of human plasma in the uptake of serotonin by human platelets.

5. The relationship between decreased 5-hydroxyindole metabolism and mental defect in phenylketonuria.

6. [Research on an ionexchange model for knowledge on the physiology of biogenic amines. Exchange equilibrium between sodium and amines on an ion-exchanger with R-PO(OH)2 as the active centers].

7. Further observations on platelet aggregation induced by adenosine diphosphate thrombin and tri-ethyl tin.

8. A study of antagonists of 5-hydroxytryptamine and catechol amines on the rat's blood pressure.

9. The effect of iproniazid and imipramine on the blood platelet 5-hydroxytrptamine level in man.

10. The effect of 5-hydroxytryptamine on the potassium exchange of human platelets.