Literature DB >> 1352259

Volume-activated Cl- secretion and transepithelial vinblastine secretion mediated by P-glycoprotein are not correlated in cultured human T84 intestinal epithelial layers.

G T McEwan1, J Hunter, B H Hirst, N L Simmons.   

Abstract

The relationship between the P-glycoprotein-mediated vinblastine secretion and cell-swelling activated Cl- secretion (conductance) in intact epithelial layers of human colonic adenocarcinoma T84 cells has been investigated. Whereas vinblastine secretion is effectively inhibited by 100 microM 1,9-dideoxy-forskolin, volume-stimulated Cl- secretion is unaffected. In contrast, 100 microM 4,4'-diisothiocyanostilbene-2,2'-disulphonic acid (DIDS) inhibited the volume-stimulated Cl- secretion, but was without effect upon transepithelial vinblastine secretion. In addition, it was noted that some epithelial layers failed to express a volume-stimulated Cl- secretion but maintained a normal level of secretory vinblastine flux.

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Year:  1992        PMID： 1352259     DOI： 10.1016/0014-5793(92)80626-r

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Antisense oligonucleotides suppress cell-volume-induced activation of chloride channels.

Authors:  M Gschwentner; U O Nagl; E Wöll; A Schmarda; M Ritter; M Paulmichl
Journal:  Pflugers Arch       Date:  1995-08       Impact factor: 3.657

2.  Failure of P-glycoprotein (MDR1) expressed in Xenopus oocytes to produce swelling-activated chloride channel activity.

Authors:  X K Morin; T D Bond; T W Loo; D M Clarke; C E Bear
Journal:  J Physiol       Date:  1995-08-01       Impact factor: 5.182

3.  Volume-activated chloride currents are not correlated with P-glycoprotein expression.

Authors:  C De Greef; J Sehrer; F Viana; K van Acker; J Eggermont; L Mertens; L Raeymaekers; G Droogmans; B Nilius
Journal:  Biochem J       Date:  1995-05-01       Impact factor: 3.857

4.  Volume-sensitive chloride currents in primary cultures of human fetal vas deferens epithelial cells.

Authors:  J P Winpenny; C J Mathews; B Verdon; C J Wardle; J A Chambers; A Harris; B E Argent; M A Gray
Journal:  Pflugers Arch       Date:  1996-08       Impact factor: 3.657

5.  P-glycoprotein is not a swelling-activated Cl- channel; possible role as a Cl- channel regulator.

Authors:  C G Vanoye; G A Altenberg; L Reuss
Journal:  J Physiol       Date:  1997-07-15       Impact factor: 5.182

6.  Functional and molecular characterization of a volume-sensitive chloride current in rat brain endothelial cells.

Authors:  S F von Weikersthal; M A Barrand; S B Hladky
Journal:  J Physiol       Date:  1999-04-01       Impact factor: 5.182

Review 7.  P-glycoprotein and cell volume-activated chloride channels.

Authors:  C F Higgins
Journal:  J Bioenerg Biomembr       Date:  1995-02       Impact factor: 2.945

8.  Characterisation of volume-activated ion transport across epithelial monolayers of human intestinal T84 cells.

Authors:  G T McEwan; C D Brown; B H Hirst; N L Simmons
Journal:  Pflugers Arch       Date:  1993-05       Impact factor: 3.657

9.  Volume-activated chloride currents in pancreatic duct cells.

Authors:  B Verdon; J P Winpenny; K J Whitfield; B E Argent; M A Gray
Journal:  J Membr Biol       Date:  1995-09       Impact factor: 1.843

Review 10.  Volume-activated chloride currents associated with the multidrug resistance P-glycoprotein.

Authors:  C F Higgins
Journal:  J Physiol       Date:  1995-01       Impact factor: 5.182
  10 in total

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