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Literature DB >> 1352246

Neuroendocrine effects of ipsapirone on the hypothalamic-pituitary adrenal axis: CRF, ACTH and cortisol in healthy volunteers.

M Beneke¹, W Wingender, R Horstmann, I Konrad-Dalhoff, H Weber, J Kuhlmann, B H Schmidt.
1. Troponwerke, Cologne, FRG.

Abstract

The neuroendocrine effects (changes in plasma CRF, ACTH and cortisol) of single and multiple (t.d.s. for 2 days) doses of ipsapirone (BAY Q 7821) 5 and 10 mg have been investigated in 6 healthy male volunteers. The study followed a balanced complete block, placebo-controlled and double blind design with two baseline phases (pre and post-treatment). Volunteers were investigated on identical days during 5 successive weeks. The results do not show a specific effect of ipsapirone on the hypothalamic-pituitary-adrenal axis when doses in the range of 5-30 mg per day were given.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 1992 PMID： 1352246 DOI： 10.1007/bf00278478

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

16 in total

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Authors: Z Liposits; C Phelix; W K Paull
Journal: Histochemistry Date: 1987

Neuroendocrine effects of ipsapirone on the hypothalamic-pituitary adrenal axis: CRF, ACTH and cortisol in healthy volunteers.

Review 1. Neuropharmacologic control of neuroendocrine function in man.

2. Effect on various putative neurotransmitters on the secretion of corticotrophin-releasing hormone from the rat hypothalamus in vitro-a model of the neurotransmitters involved.

3. Endocrine responses to 5-hydroxytryptamine-1A receptor activation by ipsapirone in humans.

4. The effects of gepirone on neuroendocrine function and temperature in humans.

Review 5. Corticosteroid inhibition of ACTH secretion.

6. Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821.

7. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists.

8. Synaptic interaction of serotonergic axons and corticotropin releasing factor (CRF) synthesizing neurons in the hypothalamic paraventricular nucleus of the rat. A light and electron microscopic immunocytochemical study.

9. Activation of the 5-HT1A receptor subtype increases rat plasma ACTH concentration.

10. The effects of gepirone and 1-(2-pyrimidinyl)-piperazine on levels of corticosterone in rat plasma.

1. The antagonism of ipsapirone induced biobehavioral responses by +/- pindolol in high and low impulsives.

2. Effects of ipsapirone in healthy subjects: a dose-response study.