Literature DB >> 1352044

The structure of celiprolol.

N Kumar1, C Strohbeck, H L Ammon.   

Abstract

The crystal structure and nuclear magnetic resonance (NMR) spectra and assignments of celiprolol, N'-[3-acetyl-4[3-[N-t-butylamino-2-hydroxypropoxy]phenyl]-N,N- diethylurea, are reported. Celiprolol crystallizes in the monoclinic space group, P2(1)/a, with a = 9.081(2), b = 13.800(4), and c = 17.471(5) A and beta = 95.04(2)degrees. Structure was solved by direct methods; structure refinement to R of 0.058. Intermolecular hydrogen-bonding in the crystal is discussed. The 1H, 13C, and two-dimensional (2D) NMR spectra of the hydrochloride have been obtained and definitive signal assignments made.

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Year:  1992        PMID： 1352044     DOI： 10.1023/a:1015895019791

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  7 in total

1.  No evidence for a direct vasodilatory effect of celiprolol on human vasculature in vivo or in vitro.

Authors:  A Hughes; G Martin; P Goldberg; S Thom; P Sever
Journal:  J Cardiovasc Pharmacol       Date:  1987-11       Impact factor: 3.105

Review 2.  Celiprolol: a new beta adrenoceptor antagonist with novel ancillary properties.

Authors:  T P Pruss; A Khandwala; P S Wolf; P Grebow; L Wong
Journal:  J Cardiovasc Pharmacol       Date:  1986       Impact factor: 3.105

3.  Haemodynamic dose-response effects of intravenous beta-blocking drugs with different ancillary properties in patients with coronary heart disease.

Authors:  S H Taylor; B Silke; P S Lee; A Hilal
Journal:  Eur Heart J       Date:  1982-12       Impact factor: 29.983

4.  Haemodynamic dose-response effects of i.v. metoprolol in coronary heart disease.

Authors:  W G Hendry; B Silke; S H Taylor
Journal:  Eur J Clin Pharmacol       Date:  1981       Impact factor: 2.953

5.  Comparison of the immediate effects of five beta-adrenoreceptor-blocking drugs with different ancillary properties in angina pectoris.

Authors:  U Thadani; C Davidson; W Singleton; S H Taylor
Journal:  N Engl J Med       Date:  1979-04-05       Impact factor: 91.245

6.  Comparative effects of metoprolol and celiprolol on cardiac hemodynamics and left ventricular volume at rest and during exercise-induced angina.

Authors:  B Silke; S P Verma; M A Frais; G Reynolds; S H Taylor
Journal:  Clin Pharmacol Ther       Date:  1986-01       Impact factor: 6.875

7.  Effects of celiprolol (REV 5320), a new cardioselective beta-adrenoceptor antagonist, on in vitro adenylate cyclase, alpha- and beta-adrenergic receptor binding and lipolysis.

Authors:  R G Van Inwegen; A Khandwala; I Weinryb; T P Pruss; E Neiss; C A Sutherland
Journal:  Arch Int Pharmacodyn Ther       Date:  1984-11
  7 in total

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