| Literature DB >> 1351750 |
R G Bardsley1, S M Allcock, J M Dawson, N W Dumelow, J A Higgins, Y V Lasslett, A K Lockley, T Parr, P J Buttery.
Abstract
Administration of beta-adrenergic agonists to domestic species can lead to skeletal muscle hypertrophy, probably by reducing the rate of myofibrillar protein breakdown. Myofibrillar breakdown is associated with the calcium-dependent proteinase system (calpains I,II and calpastatin) whose activity also changes during beta-agonist treatment. A number of growth trials using the agonists cimaterol and clenbuterol with cattle, sheep, chicken and rat are reported which suggest a general mechanism whereby beta-agonists reduce calpain I activity, but increase calpain II and calpastatin activity in skeletal muscle. Parallel changes in specific mRNAs indicate that changes in gene expression or stabilisation of mRNA could in part explain the changes in activity.Entities:
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Year: 1992 PMID： 1351750 DOI： 10.1016/0300-9084(92)90125-x
Source DB: PubMed Journal: Biochimie ISSN： 0300-9084 Impact factor: 4.079