Literature DB >> 13513911

Irreversible hemorrhagic shock in germfree rats.

B W ZWEIFACH, H A GORDON, M WAGNER, J A REYNIERS.   

Abstract

Evidence has been provided that a state of irreversible hemorrhagic shock can be induced in a bacteria-free environment in rats reared under germfree conditions. The response to bleeding, the duration of the hypotensive episode and the pathological changes were the same in the germfree and in normal stock rats. The findings are interpreted as evidence opposed to the concept that bacteria or bacterial products are implicated, as primary factors, in the pathogenicity of shock.

Entities:  

Keywords:  SHOCK/experimental

Mesh：

Year:  1958        PMID： 13513911      PMCID： PMC2136688          DOI： 10.1084/jem.107.3.437

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  9 in total

1.  Resistance to bacteria in hemorrhagic shock. II. Effect of transient vascular collapse on sensitivity to endotoxin.

Authors:  F B SCHWEINBURG; J FINE
Journal:  Proc Soc Exp Biol Med       Date:  1955-04

2.  Serum properdin levels in hemorrhagic shock.

Authors:  E FRANK; J FINE; L PILLEMER
Journal:  Proc Soc Exp Biol Med       Date:  1955-06

3.  Host resistance to bacteria in hemorrhagic shock. VI. Effect of endotoxin on antibacterial defense.

Authors:  D DAVIDOFF; J FINE; I H KOVEN; F B SCHWEINBURG
Journal:  Proc Soc Exp Biol Med       Date:  1956 Aug-Sep

4.  Factors associated with protection against experimental shock.

Authors:  S G HERSHEY; B W ZWEIFACH; W ANTOPOL
Journal:  Anesthesiology       Date:  1956-03       Impact factor: 7.892

5.  Germfree research: a basic study in host-contaminant relationship. II. Serologic observations in germfree animals.

Authors:  M WAGNER
Journal:  Bull N Y Acad Med       Date:  1955-03

6.  Germfree research: a basic study in host-contaminant relationship. III. Morphologic characterization of germfree life.

Authors:  H A GORDON
Journal:  Bull N Y Acad Med       Date:  1955-03

7.  Bacterial factor in experimental hemorrhagic shock; evidence for development of a bacterial factor which accounts for irreversibility to transfusion and for the loss of the normal capacity to destroy bacteria.

Authors:  F B SCHWEINBURG; H A FRANK; J FINE
Journal:  Am J Physiol       Date:  1954-12

8.  Bacterial action in development of irreversibility to transfusion in hemorrhagic shock in the dog.

Authors:  S JACOB; H WEIZEL; E GORDON; H KORMAN; F SCHWEINBURG; H FRANK; J FINE
Journal:  Am J Physiol       Date:  1954-12

9.  The relationship between the vascular manifestations of shock produced by endotoxin, trauma, and hemorrhage. II. The possible role of the reticulo-endothelial system in resistance to each type of shock.

Authors:  B W ZWEIFACH; B BENACERRAF; L THOMAS
Journal:  J Exp Med       Date:  1957-09-01       Impact factor: 14.307
  9 in total
  19 in total

1.  THE NATURE OF IRREVERSIBLE SHOCK: EXPERIMENTAL AND CLINICAL OBSERVATIONS.

Authors:  R C LILLEHEI; J K LONGERBEAM; J H BLOCH; W G MANAX
Journal:  Ann Surg       Date:  1964-10       Impact factor: 12.969

2.  [Effect of hypothermia and antibiotics on survival of dogs after controlled hypotension].

Authors:  V D MAGAZINOVIC; S CENIC-SUSNIK; D VARENIKA
Journal:  Pflugers Arch Gesamte Physiol Menschen Tiere       Date:  1959

3.  [MORPHOLOGIC CHANGES IN THE INTERNAL ORGANS OF RATS IN STANDARDIZED REVERSIBLE AND IRREVERSIBLE SHOCK].

Authors:  M REINERT; M PIROTH; P W HOEER; H GOERSCH
Journal:  Virchows Arch Pathol Anat Physiol Klin Med       Date:  1964-10-09

4.  The problem of irreversible shock.

Authors:  F G SMIDDY
Journal:  Postgrad Med J       Date:  1959-10       Impact factor: 2.401

5.  The intestinal factor in irreversible endotoxin shock.

Authors:  R C LILLEHEI; L D MACLEAN
Journal:  Ann Surg       Date:  1958-10       Impact factor: 12.969

6.  Studies on the absorption of Escherichia coli endotoxin from the gastrointestinal tract of dogs in the pathogenesis of irreversible hemorrhagic shock.

Authors:  J P SANFORD; H E NOYES
Journal:  J Clin Invest       Date:  1958-10       Impact factor: 14.808

7.  Studies on hemorrhagic and endotoxin shock in relation to vasomotor changes and endogenous circulating epinephrine, norepinephrine and serotonin.

Authors:  J C ROSENBERG; R C LILLEHEI; J LONGERBEAM; B ZIMMERMANN
Journal:  Ann Surg       Date:  1961-10       Impact factor: 12.969

8.  Patterns of Intestinal Ischaemia: Arris and Gale Lecture delivered at the Royal College of Surgeons of England on 6th February 1964.

Authors:  A Marston
Journal:  Ann R Coll Surg Engl       Date:  1964-09       Impact factor: 1.891

9.  Pathogenesis of Experimental Shock: I. Absence of Morphologic Evidence for Bacterial Endotoxemia.

Authors:  R T McCluskey; B W Zweifach; W Antopol; B Benacerraf; A L Nagler
Journal:  Am J Pathol       Date:  1960-09       Impact factor: 4.307

10.  Effect of intraluminal oxygen on endotoxin absorption in experimental occlusion of the superior mesenteric artery.

Authors:  K Shute
Journal:  Gut       Date:  1977-07       Impact factor: 23.059
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