Rabies antiserum interference with antigenicity of vaccine in mice.

Experimental work with mice designed to explore the interference phenomenon noted in human rabies prophylaxis is described. It was demonstrated quantitatively that when passive antibody from antiserum administration is present, active antibody response is reduced and the production of immunity to virus challenge is affected. The work appeared to confirm that the practice of giving "booster" doses of vaccine after the 10th day of treatment may overcome this interference.