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Literature DB >> 1350913

Regulation and function of cyclic nucleotides.

Abstract

Recent work has greatly expanded our knowledge of the structure, regulation and diversity of enzymes involved in the synthesis and degradation of cyclic nucleotides. This review focuses on recent work that provides insight into the structure and function of the cyclases and phosphodiesterases that regulate cyclic nucleotide metabolism. Particular emphasis is given to the roles played by multiple isoforms of each enzyme system.

Entities: Chemical

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Year: 1992 PMID： 1350913 DOI： 10.1016/0955-0674(92)90038-e

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

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Cited

12 in total

1. PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model.

Authors: Keith L Black; Dali Yin; John M Ong; Jinwei Hu; Bindu M Konda; Xiao Wang; MinHee K Ko; Jennifer-Ann Bayan; Manuel R Sacapano; Andreas Espinoza; Dwain K Irvin; Yan Shu
Journal: Brain Res Date: 2008-07-14 Impact factor: 3.252

2. Evidence for the presence of essential histidine and cysteine residues in platelet cGMP-inhibited phosphodiesterase.

Authors: F A Ghazaleh; G A Omburo; R W Colman
Journal: Biochem J Date: 1996-07-15 Impact factor: 3.857

3. Phosphodiesterase specific inhibitors control cell growth of a human neuroepithelioma cell line.

Authors: L Campagnolo; M Giorgi; G Augusti-Tocco
Journal: J Neurooncol Date: 1997-01 Impact factor: 4.130

4. Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by the type 4 phosphodiesterase (PDE-4) inhibitor, denbufylline.

Authors: A J Hadley; M Kumari; P O Cover; J Osborne; R Poyser; J D Flack; J C Buckingham
Journal: Br J Pharmacol Date: 1996-10 Impact factor: 8.739

10. Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase.

Authors: R Pillai; K Kytle; A Reyes; J Colicelli
Journal: Proc Natl Acad Sci U S A Date: 1993-12-15 Impact factor: 11.205

Regulation and function of cyclic nucleotides.

1. PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model.

2. Evidence for the presence of essential histidine and cysteine residues in platelet cGMP-inhibited phosphodiesterase.

3. Phosphodiesterase specific inhibitors control cell growth of a human neuroepithelioma cell line.

4. Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by the type 4 phosphodiesterase (PDE-4) inhibitor, denbufylline.

5. Regulation of type I adenylyl cyclase by calmodulin kinase IV in vivo.

6. cGMP Is Required for Gibberellic Acid-Induced Gene Expression in Barley Aleurone.

7. Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

8. Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases.

9. Diurnal variation of the adenylyl cyclase type 1 in the rat pineal gland.

10. Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase.