M Keating1. 1. Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City.
Abstract
BACKGROUND: Recombinant DNA technologies have facilitated the development of a set of polymorphic DNA markers covering the human genome. General linkage analysis in families predisposed to inherited disease is now feasible. Linkage analysis can help identify a disease gene even when relatively little is known about the disorder. METHODS AND RESULTS: Using this approach, we have identified linkage between a gene that causes the long QT syndrome and DNA markers on chromosome 11. CONCLUSIONS: The identification of the chromosomal location of the long QT locus is the first step in defining the specific mutations that cause this disease.
BACKGROUND: Recombinant DNA technologies have facilitated the development of a set of polymorphic DNA markers covering the human genome. General linkage analysis in families predisposed to inherited disease is now feasible. Linkage analysis can help identify a disease gene even when relatively little is known about the disorder. METHODS AND RESULTS: Using this approach, we have identified linkage between a gene that causes the long QT syndrome and DNA markers on chromosome 11. CONCLUSIONS: The identification of the chromosomal location of the long QT locus is the first step in defining the specific mutations that cause this disease.
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