Literature DB >> 1350126

Absence of selection of HIV-1 variants in vivo based on transcription/transactivation during progression to AIDS.

S Delassus1, A Meyerhans, R Cheynier, S Wain-Hobson.   

Abstract

The activity of the human immunodeficiency virus type 1 (HIV-1) transactivation protagonists tat and TAR has been analyzed from sequential primary material. The sequences were amplified from uncultured peripheral blood mononuclear cells. Despite fluctuations within the tat and TAR quasispecies there was no obvious selection for a variant encoding more powerful transactivation components either in vivo or ex vivo, indicating that this system is not exploited during disease progression. The basal levels of the natural promoters were, depending on the cell line, two- to fourfold higher than that of the reference promoter, itself derived from ex vivo adapted HIV-1 Lai.

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Year:  1992        PMID： 1350126     DOI： 10.1016/0042-6822(92)90536-x

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  10 in total

1.  Genetic drift and within-host metapopulation dynamics of HIV-1 infection.

Authors:  S D Frost; M J Dumaurier; S Wain-Hobson; A J Brown
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-29       Impact factor: 11.205

2.  A point mutation in the HIV-1 Tat responsive element is associated with postintegration latency.

Authors:  S Emiliani; C Van Lint; W Fischle; P Paras; M Ott; J Brady; E Verdin
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

3.  Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

Authors:  Eduardo O'Neill; Lillian S Kuo; John F Krisko; Diana R Tomchick; J Victor Garcia; John L Foster
Journal:  J Virol       Date:  2006-02       Impact factor: 5.103

4.  Human immunodeficiency virus type 1 long terminal repeat variants from 42 patients representing all stages of infection display a wide range of sequence polymorphism and transcription activity.

Authors:  M C Estable; B Bell; A Merzouki; J S Montaner; M V O'Shaughnessy; I J Sadowski
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

5.  Mutations in the tat gene are responsible for human immunodeficiency virus type 1 postintegration latency in the U1 cell line.

Authors:  S Emiliani; W Fischle; M Ott; C Van Lint; C A Amella; E Verdin
Journal:  J Virol       Date:  1998-02       Impact factor: 5.103

6.  Evolution of a simian immunodeficiency virus pathogen.

Authors:  P Edmonson; M Murphey-Corb; L N Martin; C Delahunty; J Heeney; H Kornfeld; P R Donahue; G H Learn; L Hood; J I Mullins
Journal:  J Virol       Date:  1998-01       Impact factor: 5.103

7.  E box motifs as mediators of proviral latency of human retroviruses.

Authors:  Jean-Michel Terme; Sébastien Calvignac; Madeleine Duc Dodon; Louis Gazzolo; Albert Jordan
Journal:  Retrovirology       Date:  2009-09-16       Impact factor: 4.602

8.  Naturally occurring human immunodeficiency virus type 1 long terminal repeats have a frequently observed duplication that binds RBF-2 and represses transcription.

Authors:  M C Estable; B Bell; M Hirst; I Sadowski
Journal:  J Virol       Date:  1998-08       Impact factor: 5.103

9.  Naturally occurring genotypes of the human immunodeficiency virus type 1 long terminal repeat display a wide range of basal and Tat-induced transcriptional activities.

Authors:  N L Michael; L D'Arcy; P K Ehrenberg; R R Redfield
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103

10.  Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort.

Authors:  Haran Sivakumaran; Bin Wang; M John Gill; Brenda Beckholdt; Nitin K Saksena; David Harrich
Journal:  Virol J       Date:  2007-10-25       Impact factor: 4.099
  10 in total

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