Literature DB >> 1350061

Effect of ethosuximide on rest tremor in the MPTP monkey model.

B Gomez-Mancilla1, J F Latulippe, R Boucher, P J Bédard.   

Abstract

Based on the hypothesis that low-threshold calcium conductance in the thalamus might be involved in the pathophysiology of parkinsonian tremor, ethosuximide was given chronically to a monkey previously treated with MPTP and displaying exceptionally a typical rest tremor. After 5 days of daily treatment, the tremor was reduced by 60%. Diltiazem and verapamil which act on different calcium channels had no such effect. Ethosuximide also potentiated the anti-tremor effect of the dopamine D2 agonist LY-171555.

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Year:  1992        PMID： 1350061     DOI： 10.1002/mds.870070207

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  9 in total

1.  Transmission of the subthalamic nucleus oscillatory activity to the cortex: a computational approach.

Authors:  Arash Hadipour Niktarash
Journal:  J Comput Neurosci       Date:  2003 Sep-Oct       Impact factor: 1.621

Review 2.  Low-voltage-activated ("T-Type") calcium channels in review.

Authors:  Anne Marie R Yunker; Maureen W McEnery
Journal:  J Bioenerg Biomembr       Date:  2003-12       Impact factor: 2.945

Review 3.  Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.

Authors:  Anne Marie R Yunker
Journal:  J Bioenerg Biomembr       Date:  2003-12       Impact factor: 2.945

4.  Generalised botulism-like syndrome after intramuscular injections of botulinum toxin type A: a report of two cases.

Authors:  A M Bakheit; C D Ward; D L McLellan
Journal:  J Neurol Neurosurg Psychiatry       Date:  1997-02       Impact factor: 10.154

Review 5.  T-type calcium channel as a new therapeutic target for tremor.

Authors:  Hideto Miwa; Tomoyoshi Kondo
Journal:  Cerebellum       Date:  2011-09       Impact factor: 3.847

6.  Ethosuximide reduces ethanol withdrawal-mediated disruptions in sleep-related EEG patterns.

Authors:  Walter F Wiggins; John D Graef; Tiffany W Huitt; Dwayne W Godwin
Journal:  Alcohol Clin Exp Res       Date:  2012-10-18       Impact factor: 3.455

7.  Anatomical localization of Cav3.1 calcium channels and electrophysiological effects of T-type calcium channel blockade in the motor thalamus of MPTP-treated monkeys.

Authors:  Annaelle Devergnas; Erdong Chen; Yuxian Ma; Ikuma Hamada; Damien Pittard; Stefan Kammermeier; Ariana P Mullin; Victor Faundez; Craig W Lindsley; Carrie Jones; Yoland Smith; Thomas Wichmann
Journal:  J Neurophysiol       Date:  2015-11-04       Impact factor: 2.714

8.  Lack of Antiparkinsonian Effects of Systemic Injections of the Specific T-Type Calcium Channel Blocker ML218 in MPTP-Treated Monkeys.

Authors:  Adriana Galvan; Annaelle Devergnas; Damien Pittard; Gunasingh Masilamoni; Jocelyn Vuong; J Scott Daniels; Ryan D Morrison; Craig W Lindsley; Thomas Wichmann
Journal:  ACS Chem Neurosci       Date:  2016-09-20       Impact factor: 4.418

9.  Ethosuximide for Essential Tremor: An Open-Label Trial.

Authors:  Alexandre Gironell; Juan Marin-Lahoz
Journal:  Tremor Other Hyperkinet Mov (N Y)       Date:  2016-07-13
  9 in total

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